Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
OPTN [cytosol]
Stable Identifier
R-BTA-9687907
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
OPTN, Q3ZC32
Locations in the PathwayBrowser
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Mitophagy (Bos taurus)
PINK1-PRKN Mediated Mitophagy (Bos taurus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Bos taurus)
OPTN [cytosol] (Bos taurus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Bos taurus)
OPTN [cytosol] (Bos taurus)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Bos taurus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Bos taurus)
OPTN [cytosol] (Bos taurus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
p-S-TBK1 phosphorylates OPTN (Bos taurus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Bos taurus)
OPTN binds TBK1 within the activated TLR4 complex (Bos taurus)
OPTN [cytosol] (Bos taurus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
TBK1 is phosphorylated within the activated TLR4 complex (Bos taurus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
OPTN binds CASP8 (Bos taurus)
OPTN [cytosol] (Bos taurus)
OPTN:CASP8 [cytosol] (Bos taurus)
OPTN [cytosol] (Bos taurus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
OPTN [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
OPTN recruits CYLD to the TNFR1 complex (Bos taurus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
OPTN [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3ZC32
Gene Names
OPTN
Reference Genes
BioGPS Gene:534150 OPTN
ENSEMBL:ENSBTAG00000016401.4
ENSEMBL:ENSBTAG00000016401.5 OPTN
KEGG Gene (Bos taurus):534150 OPTN
Monarch:534150 OPTN
NCBI Gene:534150 OPTN
Reference Transcript
RefSeq:XM_005214209.3 OPTN
RefSeq:XM_005214211.3 OPTN
RefSeq:NM_001034602.1 OPTN
RefSeq:XM_005214208.3 OPTN
Other Identifiers
534150
GO:0001920
GO:0005794
GO:0005802
GO:0005829
GO:0006914
GO:0007005
GO:0007030
GO:0008104
GO:0010508
GO:0016192
GO:0023052
GO:0030674
GO:0031593
GO:0034067
GO:0034620
GO:0042802
GO:0043001
GO:0043124
GO:0043226
GO:0048471
GO:0050829
GO:0060090
GO:0061734
GO:0070530
GO:0072659
GO:0090161
GO:0098542
GO:1904417
Participates
as an input of
OPTN binds CASP8 (Bos taurus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
OPTN binds TBK1 within the activated TLR4 complex (Bos taurus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Bos taurus)
as a component of
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
OPTN:CASP8 [cytosol] (Bos taurus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Bos taurus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Bos taurus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Bos taurus)
Other forms of this molecule
OPTN [recycling endosome membrane]
phospho-OPTN [nucleoplasm]
phospho-OPTN [cytosol]
OPTN [Golgi membrane]
phospho-OPTN [cytosol]
Inferred From
OPTN [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005214266.1
,
XP_005214268.1
,
XP_005214265.1
,
NP_001029774.1
OpenTargets
ENSG00000123240
Ensembl
ENSBTAP00000021808
,
ENSBTAG00000016401
,
ENSBTAT00000021808
VGNC
32442
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text