Reactome | OPTN [cytosol]

OPTN [cytosol]

Stable Identifier

R-BTA-9687907

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

OPTN, Q3ZC32

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q3ZC32

Gene Names

OPTN

Reference Genes

BioGPS Gene:534150 OPTN

ENSEMBL:ENSBTAG00000016401.4

KEGG:bta:534150 OPTN

Monarch:534150 OPTN

NCBI Gene:534150 OPTN

UCSC:Q3ZC32 OPTN

Reference Transcript

RefSeq:NM_001034602.1 OPTN
RefSeq:XM_025000708.2 OPTN
RefSeq:XM_005214209.3 OPTN
RefSeq:XM_005214211.5 OPTN
RefSeq:XM_059892685.1 OPTN
RefSeq:XM_005214208.5 OPTN

Other Identifiers

534150

Bt.17777.1.S1_at

Bt.17777.2.S1_at

Bt.17777.3.S1_at

GO:0008104

GO:0043124

GO:0048471

GO:0070530

Participates

as an input of

OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
OPTN binds CASP8 (Bos taurus)
OPTN binds TBK1 within the activated TLR4 complex (Bos taurus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Bos taurus)

as a component of

TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
OPTN:CASP8 [cytosol] (Bos taurus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Bos taurus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Bos taurus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Bos taurus)

Other forms of this molecule

OPTN [recycling endosome membrane]

phospho-OPTN [nucleoplasm]

phospho-OPTN [cytosol]

OPTN [Golgi membrane]

phospho-OPTN [cytosol]

Inferred From

OPTN [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005214266.1, XP_059748668.1, NP_001029774.1, XP_005214265.1, XP_024856476.1, XP_005214268.1

ENSEMBL

ENSBTAT00000021808, ENSBTAG00000016401, ENSBTAP00000021808

VGNC

32442