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GSDME [cytosol]
Stable Identifier
R-BTA-9647689
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
GSDME(1-270), E1BFC3
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
HMGB1 release from cells (Bos taurus)
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Apoptotic factor-mediated response (Bos taurus)
Release of apoptotic factors from the mitochondria (Bos taurus)
Release of Cytochrome c from mitochondria (Bos taurus)
GSDME:cardiolipin [mitochondrial outer membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
Regulated Necrosis (Bos taurus)
Pyroptosis (Bos taurus)
CASP3 cleaves GSDME (Bos taurus)
GSDME [cytosol] (Bos taurus)
GSDME (1-270) binds PIPs (Bos taurus)
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
GSDME [cytosol] (Bos taurus)
GSDME (1-270) binds cardiolipin (Bos taurus)
GSDME [cytosol] (Bos taurus)
GSDME:cardiolipin [mitochondrial outer membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
GSDME oligomerizes (Bos taurus)
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
GSDME [cytosol] (Bos taurus)
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
GZMB cleaves GSDME (Bos taurus)
GSDME [cytosol] (Bos taurus)
HMGB1 release from cells (Bos taurus)
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
Release of Cytochrome c from mitochondria (Bos taurus)
GSDME:cardiolipin [mitochondrial outer membrane] (Bos taurus)
GSDME [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BFC3
Gene Names
GSDME
Reference Genes
BioGPS Gene:616398 GSDME
ENSEMBL:ENSBTAG00000015326.5
ENSEMBL:ENSBTAG00000015326.6 GSDME
KEGG Gene (Bos taurus):616398 GSDME
Monarch:616398 GSDME
NCBI Gene:616398 GSDME
Reference Transcript
RefSeq:NM_001193112.1 GSDME
Other Identifiers
616398
GO:0002376
GO:0002839
GO:0005215
GO:0005546
GO:0005737
GO:0005829
GO:0005886
GO:0008285
GO:0008289
GO:0012501
GO:0016020
GO:0022829
GO:0023052
GO:0030154
GO:0042491
GO:0043410
GO:0048856
GO:0070269
GO:0071356
GO:0098586
GO:1901612
GO:2001244
Participates
as an input of
GSDME oligomerizes (Bos taurus)
GSDME (1-270) binds cardiolipin (Bos taurus)
GSDME (1-270) binds PIPs (Bos taurus)
as an output of
GZMB cleaves GSDME (Bos taurus)
CASP3 cleaves GSDME (Bos taurus)
as a component of
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
GSDME:cardiolipin [mitochondrial outer membrane] (Bos taurus)
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
Other forms of this molecule
GSDME [cytosol]
GSDME [cytosol]
Inferred From
GSDME(1-270) [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001180041.1
OpenTargets
ENSG00000105928
Ensembl
ENSBTAT00000020371
,
ENSBTAT00000080428
,
ENSBTAP00000070549
,
ENSBTAG00000015326
,
ENSBTAP00000020371
VGNC
28019
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