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EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Stable Identifier
R-BTA-9624425
Type
Complex
Species
Bos taurus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
PTK2 autophosphorylates downstream of EGFR (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
PTK2 binds activated EGFR (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR autophosphorylation (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGFR downregulation (Bos taurus)
Binding of CBL to EGFR (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
CBL ubiquitinates Sprouty (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Localization of CBL:GRB2 to the membrane (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Phosphorylation of CBL (EGFR:CBL) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGFR interacts with phospholipase C-gamma (Bos taurus)
Active PLC-gamma1 dissociates from EGFR (Bos taurus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
GAB1 signalosome (Bos taurus)
Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Dephosphorylation of PAG by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
GAB1 phosphorylation by EGFR kinase (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Sustained activation of SRC kinase by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
GRB2 events in EGFR signaling (Bos taurus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
Phosphorylation of EGFR by SRC kinase (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
SHC1 events in EGFR signaling (Bos taurus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
EGF-like ligands [extracellular region]
(Bos taurus)
x 2
phospho-p-6Y-EGFR [plasma membrane]
(Bos taurus)
Participates
as a component of
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Bos taurus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
as an input of
PTK2 binds activated EGFR (Bos taurus)
Binding of CBL to EGFR (Bos taurus)
Localization of CBL:GRB2 to the membrane (Bos taurus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Bos taurus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Bos taurus)
GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)
as an output of
Active PLC-gamma1 dissociates from EGFR (Bos taurus)
EGFR autophosphorylation (Bos taurus)
Phosphorylation of EGFR by SRC kinase (Bos taurus)
Inferred From
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Homo sapiens)
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