Reactome | ATP6V1G2 [cytosol]

ATP6V1G2 [cytosol]

Stable Identifier

R-BTA-912588

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

ATP6V1G2, Q0VCV6

Locations in the PathwayBrowser

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Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular response to starvation (Bos taurus)
    - Amino acids regulate mTORC1 (Bos taurus)
      - RRAGA,B exchanges GDP for GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - RRAGA,B hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - RRAGC,D exchanges GTP for GDP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - RRAGC,D hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - mTORC1 binds RHEB:GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by Insulin receptor (Bos taurus)
    - Insulin receptor recycling (Bos taurus)
      - ATP6AP1 binds V-ATPase (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - Endosome acidification (Bos taurus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)

Transport of small molecules (Bos taurus)

- Ion channel transport (Bos taurus)
  - ATP6AP1 binds V-ATPase (Bos taurus)
    - V-ATPase [endosome membrane] (Bos taurus)
      - ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
      - V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
- Iron uptake and transport (Bos taurus)
  - Transferrin endocytosis and recycling (Bos taurus)
    - ATP6AP1 binds V-ATPase (Bos taurus)
      - V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)
    - Acidification of Tf:TfR1 containing endosome (Bos taurus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1G dimer [cytosol] (Bos taurus)
        
        ATP6V1G [cytosol] (Bos taurus)
        
        ATP6V1G2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q0VCV6

Gene Names

ATP6V1G2

Reference Genes

BioGPS Gene:514368 ATP6V1G2

ENSEMBL:ENSBTAG00000014491

ENSEMBL:ENSBTAG00000014491.4 ATP6V1G2

KEGG Gene (Bos taurus):514368 ATP6V1G2

Monarch:514368 ATP6V1G2

NCBI Gene:514368 ATP6V1G2

Reference Transcript

RefSeq:NM_001075664.1 ATP6V1G2

Other Identifiers

514368

GO:0003824

GO:0005215

GO:0005773

GO:0016192

GO:0016471

GO:0016787

GO:0016887

GO:0030672

GO:0031410

GO:0043226

GO:0046961

GO:0055085

GO:0097401

GO:0140657

GO:1902600

Participates

as a member of

ATP6V1G [cytosol] (Bos taurus)

Inferred From

ATP6V1G2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001069132.1

OpenTargets

ENSG00000213760

Ensembl

ENSBTAT00000019267, ENSBTAP00000019267, ENSBTAG00000014491

VGNC

57164

PDB

7UNE, 6XBW, 6XBY, 7KHR

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