Reactome | RUNX2 [nucleoplasm]

RUNX2 [nucleoplasm]

Stable Identifier

R-BTA-9008125

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

PolyUb-RUNX2-P1, A0A3Q1MKY5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional regulation by RUNX2 (Bos taurus)
      - Regulation of RUNX2 expression and activity (Bos taurus)
        
        SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)
        
        RUNX2 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1MKY5

Gene Names

RUNX2

Reference Genes

ENSEMBL:ENSBTAG00000004104

Other Identifiers

536911

GO:0000228

GO:0000790

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0001501

GO:0001503

GO:0001649

GO:0001958

GO:0002051

GO:0002062

GO:0002063

GO:0002076

GO:0002376

GO:0003674

GO:0003677

GO:0003682

GO:0003700

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0006355

GO:0006357

GO:0007165

GO:0008134

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0009790

GO:0010468

GO:0010628

GO:0019904

GO:0021700

GO:0030097

GO:0030154

GO:0030182

GO:0030217

GO:0030278

GO:0030509

GO:0032332

GO:0032991

GO:0034641

GO:0035115

GO:0040036

GO:0042475

GO:0042487

GO:0043167

GO:0043226

GO:0043425

GO:0045595

GO:0045667

GO:0045669

GO:0045879

GO:0045892

GO:0045893

GO:0045944

GO:0048469

GO:0048701

GO:0048705

GO:0048856

GO:0048863

GO:0070491

GO:0071773

GO:1901522

GO:1990837

Participant Of

output

SCF(SKP2) polyubiquitinates RUNX2

Other forms of this molecule

phospho-RUNX2 [nucleoplasm]

RUNX2 [nucleoplasm]

RUNX2 [cytosol]

phospho-RUNX2 [nucleoplasm]

RUNX2 [cytosol]

RUNX2 [nucleoplasm]

Inferred From

PolyUb-RUNX2-P1 [nucleoplasm] (Homo sapiens)

PolyUb-RUNX2 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at unknown position

Modification

polyubiquitin chain [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

OpenTargets

ENSG00000124813

Ensembl

ENSBTAP00000072258, ENSBTAT00000066565, ENSBTAG00000004104

VGNC

34220

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