Reactome | CAPZA3 [cytosol]

CAPZA3 [cytosol]

Stable Identifier

R-BTA-8982306

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

CAPZA3, Q32KS3

Locations in the PathwayBrowser

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Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)
      - Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - MHC class II antigen presentation (Bos taurus)
    - Transport of antigen loaded MHC II molecules to surface (Bos taurus)
      - Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
      - Kinesins:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Asparagine N-linked glycosylation (Bos taurus)
    - Transport to the Golgi and subsequent modification (Bos taurus)
      - ER to Golgi Anterograde Transport (Bos taurus)
        
        COPI-mediated anterograde transport (Bos taurus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - ER to Golgi Anterograde Transport (Bos taurus)
    - COPI-mediated anterograde transport (Bos taurus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
    - Golgi-to-ER retrograde transport (Bos taurus)
      - COPI-independent Golgi-to-ER retrograde traffic (Bos taurus)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Bos taurus)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Bos taurus)
        
        Dynein:Dynactin:microtubule [cytosol] (Bos taurus)
        
        Dynactin [cytosol] (Bos taurus)
        
        Dynactin rod [cytosol] (Bos taurus)
        
        CAPZ [cytosol] (Bos taurus)
        
        CAPZA3:CAPZB [cytosol] (Bos taurus)
        
        CAPZA3 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q32KS3

Gene Names

CAPZA3

Reference Genes

BioGPS Gene:539160 CAPZA3

ENSEMBL:ENSBTAG00000013207.5

KEGG Gene (Bos taurus):539160 CAPZA3

Monarch:539160 CAPZA3

NCBI Gene:539160 CAPZA3

Reference Transcript

RefSeq:NM_001040561.2 CAPZA3

Participates

as a component of

CAPZA3:CAPZB [cytosol] (Bos taurus)

Inferred From

CAPZA3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001035651.1

OpenTargets

ENSG00000177938

VGNC

26758

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