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PTEN [cytosol]
Stable Identifier
R-BTA-8948777
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
K48polyUb-K289-PTEN, F1MDX9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN stability and activity (Bos taurus)
MKRN1 polyubiquitinates PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
Proteasome degrades polyubiquitinated PTEN (Bos taurus)
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MDX9
Gene Names
PTEN
Reference Genes
ENSEMBL:ENSBTAG00000009498.6
ENSEMBL:ENSBTAG00000009498.7 PTEN
Other Identifiers
540786
Participates
as a member of
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Bos taurus)
as an output of
MKRN1 polyubiquitinates PTEN (Bos taurus)
as an input of
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
Other forms of this molecule
PTEN [cytosol]
PTEN [nucleoplasm]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
PTEN [nucleoplasm]
PTEN [nucleoplasm]
PTEN [cytosol]
Inferred From
PolyUb-PTEN,K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 289 (in Homo sapiens)
Coordinate
289
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
OpenTargets
ENSG00000171862
Ensembl
ENSBTAG00000009498
,
ENSBTAT00000012499
,
ENSBTAP00000012499
VGNC
33496
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