Reactome | VRK3 [nucleoplasm]

VRK3 [nucleoplasm]

Stable Identifier

R-BTA-8942507

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

VRK3, Q2YDN8

Locations in the PathwayBrowser

Expand all

Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-17 signaling (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Toll-like Receptor Cascades (Bos taurus)
    - Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
      - MyD88-independent TLR4 cascade (Bos taurus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by NTRKs (Bos taurus)
    - Signaling by NTRK1 (TRKA) (Bos taurus)
      - Nuclear Events (kinase and transcription factor activation) (Bos taurus)
        
        ERK/MAPK targets (Bos taurus)
        
        ERKs are inactivated (Bos taurus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
        
        VRK3:DUSP3 [nucleoplasm] (Bos taurus)
        
        VRK3 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q2YDN8

Gene Names

VRK3

Reference Genes

BioGPS Gene:520302 VRK3

ENSEMBL:ENSBTAG00000005367

ENSEMBL:ENSBTAG00000005367.4 VRK3

KEGG Gene (Bos taurus):520302 VRK3

Monarch:520302 VRK3

NCBI Gene:520302 VRK3

Reference Transcript

Other Identifiers

520302

GO:0003824

GO:0004672

GO:0005524

GO:0005634

GO:0005654

GO:0006468

GO:0007519

GO:0016740

GO:0019903

GO:0023052

GO:0036211

GO:0043226

GO:0043231

GO:0048856

GO:0070373

GO:0140096

Participates

as a component of

VRK3:DUSP3 [nucleoplasm] (Bos taurus)

Inferred From

VRK3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_015313652.1, XP_010813351.1, NP_001039716.1, XP_005219336.1, XP_005219337.1, XP_005219338.1

OpenTargets

ENSG00000105053

Ensembl

ENSBTAT00000007054, ENSBTAG00000005367, ENSBTAP00000007054

VGNC

36836

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