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PIK3R1 [cytosol]
Stable Identifier
R-BTA-74789
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
PIK3R1, P23727
Locations in the PathwayBrowser for interactor UniProt:P23727
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GP1b-IX-V activation signalling (Bos taurus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)
PIK3R1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)
PIK3R1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)
PIK3R1 [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)
PIK3R1 [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)
PIK3R1 [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)
PIK3R1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P23727
Gene Names
PIK3R1
Reference Genes
BioGPS Gene:282307 PIK3R1
ENSEMBL:ENSBTAG00000010989
ENSEMBL:ENSBTAG00000010989.6 PIK3R1
KEGG Gene (Bos taurus):282307 PIK3R1
Monarch:282307 PIK3R1
NCBI Gene:282307 PIK3R1
Reference Transcript
RefSeq:NM_174575.1 PIK3R1
RefSeq:XM_005221436.3 PIK3R1
Other Identifiers
282307
GO:0001678
GO:0005068
GO:0005158
GO:0005159
GO:0005515
GO:0005634
GO:0005942
GO:0005943
GO:0006351
GO:0006355
GO:0006629
GO:0006886
GO:0006913
GO:0007155
GO:0007165
GO:0008286
GO:0012501
GO:0015031
GO:0023052
GO:0032869
GO:0033120
GO:0034446
GO:0034976
GO:0035014
GO:0042307
GO:0042802
GO:0043066
GO:0043125
GO:0043226
GO:0043491
GO:0043548
GO:0043560
GO:0045944
GO:0046326
GO:0046854
GO:0046935
GO:0048009
GO:0050821
GO:0055085
GO:0060090
GO:0072659
GO:0098772
GO:0140767
GO:0141038
GO:1900103
GO:1903078
Participates
as a candidate of
RND2 effectors [cytosol] (Bos taurus)
RHOA GAPs [cytosol] (Bos taurus)
RND3 effectors [cytosol] (Bos taurus)
RHOC GAPs [cytosol] (Bos taurus)
RHOV effectors [cytosol] (Bos taurus)
CDC42 GAPs [cytosol] (Bos taurus)
RAC2 GAPs [cytosol] (Bos taurus)
RHOD GAPs [cytosol] (Bos taurus)
RAC1 GAPs [cytosol] (Bos taurus)
RHOF GAPs [cytosol] (Bos taurus)
RHOG GAPs [cytosol] (Bos taurus)
RHOJ GAPs [cytosol] (Bos taurus)
RAC3 GAPs [cytosol] (Bos taurus)
RND1 effectors [cytosol] (Bos taurus)
PI3K regulatory subunits [cytosol] (Bos taurus)
as a member of
RHOU effectors [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
as an input of
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)
as a component of
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Bos taurus)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Bos taurus)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [cytosol] (Bos taurus)
PIK3CB:PIK3R1 [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
Other forms of this molecule
PIK3R1 [plasma membrane]
PIK3R1 [cytosol]
Inferred From
PIK3R1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005221493.1
,
NP_777000.1
OpenTargets
ENSG00000145675
Ensembl
ENSBTAT00000014594
,
ENSBTAG00000010989
,
ENSBTAP00000014594
VGNC
32894
PDB
6OCO
,
6G6W
,
1BFI
,
1OO3
,
6D85
,
6R4R
,
5DXU
,
6MRP
,
6D86
,
1QAD
,
2PNB
,
7JIS
,
5T8F
,
5DXH
,
6OCU
,
6D81
,
2PNA
,
2PNI
,
6D87
,
1PNJ
,
8BCY
,
6D82
,
1OO4
,
1BFJ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.725
6
UniProt:P23727
3
PIK3R1 [plasma membrane]
(R-BTA-198365)
PIK3R1 [cytosol]
(R-BTA-74789)
PIK3R1 [cytosol]
(R-BTA-3080572)
0.624
4
UniProt:P20339 RAB5A
7
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
0.558
5
UniProt:P32871
1
PIK3CA [cytosol]
(R-BTA-74787)
0.524
4
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