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phospho-IRS2 [cytosol]
Stable Identifier
R-BTA-74774
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
p-Y-IRS2, F1MJE0
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K bound to EPOR [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS activation (Bos taurus)
Dissociation of IRS-P from insulin receptor (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
Phosphorylation of IRS (Bos taurus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
SOS-mediated signalling (Bos taurus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
Signal attenuation (Bos taurus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
SOS-mediated signalling (Bos taurus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
phospho-IRS2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MJE0
Gene Names
IRS2
Reference Genes
ENSEMBL:ENSBTAG00000012019.6
Other Identifiers
100300012
GO:0005158
GO:0005829
GO:0005886
GO:0007165
GO:0008286
GO:0023052
GO:0043548
Participates
as a component of
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Bos taurus)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
Other forms of this molecule
IRS2 [plasma membrane]
IRS2 [cytosol]
phospho-IRS2 [plasma membrane]
Inferred From
p-Y-IRS2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000185950
Ensembl
ENSBTAP00000049448
,
ENSBTAG00000012019
,
ENSBTAT00000015938
VGNC
30284
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