Gnat1-GTP binds Pde6 and activates it

Stable Identifier
R-BTA-74066
Type
Reaction [binding]
Species
Bos taurus
Compartment
ReviewStatus
5/5
General
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Gnat1-GTP binds Pde6 and activates it
Cyclic-GMP-dependent phosphodiesterase 6 (Pde6) is a membrane-associated enzyme consisting of two catalytic subunits and two auto-inhibitory (PDE-gamma) subunits. Binding of activated transducin alpha subunit (Gnat1-GTP) to one PDE-gamma causes a conformational change of the key inhibitory C-terminal domain of the latter that relieves the inhibition on the associated catalytic subunit. Two Gnat1-GTP molecules are able to bind to Pde6 (Guo & Ruoho 2008, Baehr et al. 1979, Catty et al. 1992, Deterre et al. 1988, Fung & Stryer 1981, Hurley & Stryer 1982, Sitaramayya et al. 1986).
Literature References
PubMed ID Title Journal Year
6286681 Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments

Stryer, L, Hurley, JB

J Biol Chem 1982
2833739 cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits

Robert, M, Deterre, P, Chabre, M, Bigay, J, Forquet, F

Proc. Natl. Acad. Sci. U.S.A. 1988
19075750 The retinal cGMP phosphodiesterase gamma-subunit - a chameleon

Guo, LW, Ruoho, AE

Curr. Protein Pept. Sci. 2008
3006765 Kinetic studies suggest that light-activated cyclic GMP phosphodiesterase is a complex with G-protein subunits

Sitaramayya, A, Liebman, PA, Harkness, J, Parkes, JH, Gonzalez-Oliva, C

Biochemistry 1986
6264430 Flow of information in the light-triggered cyclic nucleotide cascade of vision

Fung, BK, Hurley, JB, Stryer, L

Proc. Natl. Acad. Sci. U.S.A. 1981
1326553 The cGMP phosphodiesterase-transducin complex of retinal rods. Membrane binding and subunits interactions

Deterre, P, Pfister, C, Catty, P, Bruckert, F

J. Biol. Chem. 1992
227876 Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments

Devlin, MJ, Applebury, ML, Baehr, W

J. Biol. Chem. 1979
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Orthologous Events
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