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ORC4 [nucleoplasm]
Stable Identifier
R-BTA-68519
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
Q2YDI2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G2/M Checkpoints (Bos taurus)
Activation of ATR in response to replication stress (Bos taurus)
Activation of claspin (Bos taurus)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Loading of claspin onto DNA during replication origin firing (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G1 phase and G1/S transition (Bos taurus)
G1/S Transition (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Cdt1 is displaced from the pre-replicative complex. (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
DNA polymerase alpha:primase binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
DNA polymerase epsilon binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)
MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
S Phase (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
DNA Replication (Bos taurus)
DNA Replication Pre-Initiation (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Cdt1 is displaced from the pre-replicative complex. (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
DNA polymerase alpha:primase binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
DNA polymerase epsilon binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
active pre-replicative complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)
MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Assembly of the pre-replicative complex (Bos taurus)
Assembly of the ORC complex at the origin of replication (Bos taurus)
Formation of ORC(1-5) complex (Bos taurus)
ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5) [nucleoplasm] (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Formation of ORC(1-6) complex (Bos taurus)
ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5) [nucleoplasm] (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
ORC(1-6):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5) [nucleoplasm] (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Formation of ORC(2-5) complex (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
CDC6 association with the ORC:origin complex (Bos taurus)
CDC6 association with ORC(1-6) at replication origins (Bos taurus)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Bos taurus)
ORC(1-6):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5) [nucleoplasm] (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
ORC(1-6):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
ORC(1-5) [nucleoplasm] (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
pre-replicative complex [nucleoplasm] (Bos taurus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
ORC4 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q2YDI2
Reference Genes
BioGPS Gene:529245
ENSEMBL:ENSBTAG00000015291
ENSEMBL:ENSBTAG00000015291.6
KEGG Gene (Bos taurus):529245
Monarch:529245
NCBI Gene:529245
Reference Transcript
RefSeq:NM_001046301.2
RefSeq:XM_005202444.3
Other Identifiers
529245
GO:0000808
GO:0003677
GO:0003824
GO:0005634
GO:0005694
GO:0006260
GO:0016787
GO:0016887
GO:0043226
GO:0140657
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Bos taurus)
ORC(2-5) [nucleoplasm] (Bos taurus)
ORC:origin of replication [nucleoplasm] (Bos taurus)
as an input of
Formation of ORC(2-5) complex (Bos taurus)
Inferred From
ORC4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_005202501.1
,
NP_001039766.1
Ensembl
ENSBTAG00000015291
,
ENSBTAP00000058035
,
ENSBTAT00000079417
VGNC
32449
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