Reactome | INTS4 [nucleoplasm]

INTS4 [nucleoplasm]

Stable Identifier

R-BTA-6807462

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

INTS4, E1BLD2

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - RNA polymerase II transcribes snRNA genes (Bos taurus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
    - Integrator complex processes the 3' end of snRNA (Bos taurus)
      - Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
      - Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS4 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BLD2

Gene Names

INTS4

Reference Genes

BioGPS Gene:505657 INTS4

ENSEMBL:ENSBTAG00000010505.7

KEGG Gene (Bos taurus):505657 INTS4

Monarch:505657 INTS4

NCBI Gene:505657 INTS4

Reference Transcript

RefSeq:NM_001110065.2 INTS4

Other Identifiers

505657

GO:0005634

GO:0016073

GO:0016180

GO:0032039

GO:0043226

Participates

as a component of

Integrator [nucleoplasm] (Bos taurus)

Inferred From

INTS4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001103535.2

OpenTargets

ENSG00000149262

Ensembl

ENSBTAT00000061534, ENSBTAG00000010505, ENSBTAP00000053790

VGNC

30230