Reactome | INTS12 [nucleoplasm]

INTS12 [nucleoplasm]

Stable Identifier

R-BTA-6807456

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

INTS12, Q32LL5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - RNA polymerase II transcribes snRNA genes (Bos taurus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
    - Integrator complex processes the 3' end of snRNA (Bos taurus)
      - Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
      - Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS12 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q32LL5

Gene Names

INTS12

Reference Genes

BioGPS Gene:517489 INTS12

ENSEMBL:ENSBTAG00000033648

ENSEMBL:ENSBTAG00000033648.4 INTS12

KEGG Gene (Bos taurus):517489 INTS12

Monarch:517489 INTS12

NCBI Gene:517489 INTS12

Reference Transcript

Other Identifiers

517489

Participates

as a component of

Integrator [nucleoplasm] (Bos taurus)

Inferred From

INTS12 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005207666.1, NP_001069221.1

OpenTargets

ENSG00000138785

Ensembl

ENSBTAT00000047799, ENSBTAG00000033648, ENSBTAP00000044968

VGNC

30225