Reactome | GTF2F2 [nucleoplasm]

GTF2F2 [nucleoplasm]

Stable Identifier

R-BTA-65567

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

GTF2F2, Q2T9L9

Locations in the PathwayBrowser

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Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - TP53 Regulates Transcription of DNA Repair Genes (Bos taurus)
        
        CCNK:CDK12 binds RNA Pol II at DNA repair genes (Bos taurus)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Bos taurus)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Bos taurus)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - RNA Pol II CTD phosphorylation and interaction with CE (Bos taurus)
    - Activation of GT (Bos taurus)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Bos taurus)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Phosphorylation (Ser5) of RNA pol II CTD (Bos taurus)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RNA Polymerase II CTD (phosphorylated) binds to CE (Bos taurus)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - RNA Polymerase II Pre-transcription Events (Bos taurus)
    - 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)
      - Paused processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Abortive Initiation After Second Transition (Bos taurus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Abortive Initiation Before Second Transition (Bos taurus)
      - Pol II Promoter Escape Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Abortive initiation after formation of the first phosphodiester bond (Bos taurus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - pol II transcription complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Abortive termination of early transcription elongation by DSIF:NELF (Bos taurus)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Abortive termination of elongation after arrest (Bos taurus)
      - Aborted elongation complex after arrest [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Fall Back to Closed Pre-initiation Complex (Bos taurus)
      - pol II closed pre-initiation complex [nucleoplasm] (Bos taurus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - pol II open pre-initiation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Resumption of elongation after recovery from pausing (Bos taurus)
      - Paused processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - TFIIS-mediated recovery of elongation from arrest (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - RNA Polymerase II Transcription Elongation (Bos taurus)
    - Addition of nucleotides leads to transcript elongation (Bos taurus)
      - Elongation complex [nucleoplasm] (Bos taurus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Formation of RNA Pol II elongation complex (Bos taurus)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Formation of the Early Elongation Complex (Bos taurus)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Formation of DSIF:NELF:early elongation complex (Bos taurus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Bos taurus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Bos taurus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Pol II elongation complex moves on the template as transcript elongates (Bos taurus)
      - Elongation complex prior to separation [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Separation of elongating transcript from template (Bos taurus)
      - Elongation complex prior to separation [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Elongation complex with separated and uncleaved transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - RNA Polymerase II Transcription Initiation And Promoter Clearance (Bos taurus)
    - RNA Polymerase II Promoter Escape (Bos taurus)
      - Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Addition of nucleotides between position +11 and +30 (Bos taurus)
        
        Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Addition of the third nucleotide on the nascent transcript (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Unwinding DNA for the nascent transcript (Bos taurus)
        
        pol II transcription complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Unwinding of DNA for the Nascent Transcript: Second Transition (Bos taurus)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RNA Polymerase II Promoter Opening: First Transition (Bos taurus)
      - pol II closed pre-initiation complex [nucleoplasm] (Bos taurus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - pol II open pre-initiation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RNA Polymerase II Transcription Initiation (Bos taurus)
      - NTP Binds Active Site of RNA Polymerase II (Bos taurus)
        
        Pol II initiation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II open pre-initiation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Newly Formed Phosphodiester Bond Stabilized and PPi Released (Bos taurus)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        pol II transcription complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Bos taurus)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        Pol II initiation complex [nucleoplasm] (Bos taurus)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (Bos taurus)
    - Binding of TFIIE to the growing preinitiation complex (Bos taurus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Bos taurus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Formation of the closed pre-initiation complex (Bos taurus)
      - pol II closed pre-initiation complex [nucleoplasm] (Bos taurus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Bos taurus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Bos taurus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - RNA polymerase II transcribes snRNA genes (Bos taurus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Integrator complex processes the 3' end of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)

Metabolism of RNA (Bos taurus)

- Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
  - Formation of pre-mRNPs (Bos taurus)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
      - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Internal Methylation of mRNA (Bos taurus)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Bos taurus)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - mRNA Splicing (Bos taurus)
    - mRNA Splicing - Major Pathway (Bos taurus)
      - Formation of the Spliceosomal Bact complex (Bos taurus)
        
        Spliceosomal B complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        Spliceosomal Bact complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal C* complex (Bos taurus)
        
        Spliceosomal C complex [nucleoplasm] (Bos taurus)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        Spliceosomal C* complex [nucleoplasm] (Bos taurus)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal E complex (Bos taurus)
        
        Spliceosomal E complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal P complex and exon ligation (Bos taurus)
        
        Spliceosomal C* complex [nucleoplasm] (Bos taurus)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        Spliceosomal P complex [nucleoplasm] (Bos taurus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - mRNA Splicing - Minor Pathway (Bos taurus)
      - ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Bos taurus)
        
        ATAC C Complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        post exon ligation complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Bos taurus)
        
        ATAC C Complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Formation of AT-AC B Complex (Bos taurus)
        
        ATAC A Complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        ATAC B Complex [nucleoplasm] (Bos taurus)
        
        ATAC A Complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - Formation of AT-AC C complex (Bos taurus)
        
        ATAC B Complex [nucleoplasm] (Bos taurus)
        
        ATAC A Complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        ATAC C Complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
- mRNA Capping (Bos taurus)
  - Activation of GT (Bos taurus)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Capping complex formation (Bos taurus)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Capping complex (initial) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Dissociation of transcript with 5'-GMP from GT (Bos taurus)
    - Capping complex (GpppN..) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Formation of the CE:GMP intermediate complex (Bos taurus)
    - Capping complex (intermediate) [nucleoplasm] (Bos taurus)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Bos taurus)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Capping complex (hydrolyzed) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Bos taurus)
    - Capping complex (hydrolyzed) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Capping complex (initial) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Methylation of GMP-cap by RNA Methyltransferase (Bos taurus)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Bos taurus)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Bos taurus)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Bos taurus)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Bos taurus)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Bos taurus)
    - Capping complex (intermediate) [nucleoplasm] (Bos taurus)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Bos taurus)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
    - Capping complex (GpppN..) [nucleoplasm] (Bos taurus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Nuclear Receptors (Bos taurus)
  - ESR-mediated signaling (Bos taurus)
    - Estrogen-dependent gene expression (Bos taurus)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Bos taurus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by FGFR (Bos taurus)
    - Signaling by FGFR2 (Bos taurus)
      - FGFR2 alternative splicing (Bos taurus)
        
        PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Bos taurus)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Bos taurus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Bos taurus)
        
        TFIIF [nucleoplasm] (Bos taurus)
        
        GTF2F2 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q2T9L9

Gene Names

GTF2F2

Reference Genes

BioGPS Gene:509259 GTF2F2

ENSEMBL:ENSBTAG00000034495.4 GTF2F2

ENSEMBL:ENSBTAG00000049772

ENSEMBL:ENSBTAG00000049772.1 GTF2F2

KEGG Gene (Bos taurus):509259 GTF2F2

Monarch:509259 GTF2F2

NCBI Gene:509259 GTF2F2

Reference Transcript

RefSeq:NM_001038064.1 GTF2F2

Other Identifiers

112449302

509259

GO:0005634

GO:0005654

GO:0005674

GO:0006351

GO:0006366

GO:0006367

GO:0043226

Participates

as a component of

TFIIF [nucleoplasm] (Bos taurus)

Inferred From

GTF2F2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001033153.1

OpenTargets

ENSG00000188342

Ensembl

ENSBTAP00000045836, ENSBTAT00000048870, ENSBTAP00000061447, ENSBTAG00000034495, ENSBTAG00000049772, ENSBTAT00000078070

VGNC

53815

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