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MAPK3 [cytosol]
Stable Identifier
R-BTA-59284
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
E1B8P9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
L1CAM interactions (Bos taurus)
Signal transduction by L1 (Bos taurus)
MAP2K1 phosphorylates MAPK3 (Bos taurus)
p-2S-MAP2K1:MAPK3 [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
F2R:ARRB1 binds MAPKs, SRC-1 (Bos taurus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
F2R:ARRB2 binds MAPKs, SRC-1 (Bos taurus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
SRC-1 bound to ARRB2 is not activated (Bos taurus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Bos taurus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Growth hormone receptor signaling (Bos taurus)
Lyn activates ERK (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
ISG15 antiviral mechanism (Bos taurus)
ISGylation of host proteins (Bos taurus)
ISG15 targets [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
ISGylated host proteins [cytosol] (Bos taurus)
ISG15 targets [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Bos taurus)
ISG15 targets [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
ISGylated host proteins [cytosol] (Bos taurus)
ISG15 targets [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Interferon gamma signaling (Bos taurus)
IFNG signaling activates MAPKs (Bos taurus)
JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
MAPK monomers and dimers [cytosol] (Bos taurus)
MAPK3 dimer [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAPK3 (ERK1) activation (Bos taurus)
MAP2K1 binds MAPK3 (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
p-2S-MAP2K1:MAPK3 [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAP2K1 phosphorylates MAPK3 (Bos taurus)
p-2S-MAP2K1:MAPK3 [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
MAPK monomers and dimers [cytosol] (Bos taurus)
MAPK3 dimer [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
Signal attenuation (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)
MAPK3,(MAPK1) [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)
MAPK3,(MAPK1) [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK3 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1B8P9
Reference Genes
ENSEMBL:ENSBTAG00000016156.5
ENSEMBL:ENSBTAG00000016156.6
Other Identifiers
531391
GO:0000165
GO:0000166
GO:0001784
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005524
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006351
GO:0006355
GO:0006914
GO:0006974
GO:0007010
GO:0008286
GO:0009887
GO:0010759
GO:0014032
GO:0014044
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019233
GO:0019902
GO:0023052
GO:0030154
GO:0030278
GO:0030509
GO:0030641
GO:0030878
GO:0031143
GO:0031410
GO:0031663
GO:0032200
GO:0032212
GO:0032496
GO:0032872
GO:0034198
GO:0034614
GO:0035556
GO:0038133
GO:0042473
GO:0042552
GO:0042770
GO:0042802
GO:0043226
GO:0043330
GO:0045944
GO:0048009
GO:0048538
GO:0048856
GO:0048870
GO:0050804
GO:0050877
GO:0051216
GO:0051403
GO:0051493
GO:0060020
GO:0060324
GO:0060425
GO:0060440
GO:0061308
GO:0070371
GO:0070374
GO:0070498
GO:0070849
GO:0071260
GO:0071276
GO:0071356
GO:0072584
GO:0090170
GO:0098542
GO:0098792
GO:0098978
GO:0106310
GO:0120041
GO:0140096
GO:0140297
GO:1904262
GO:1904355
GO:1904417
GO:2000641
Participates
as a member of
ISG15 targets [cytosol] (Bos taurus)
MAPK3,(MAPK1) [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
as a component of
MAPK3 dimer [cytosol] (Bos taurus)
p-2S-MAP2K1:MAPK3 [cytosol] (Bos taurus)
as an input of
MAP2K1 binds MAPK3 (Bos taurus)
Other forms of this molecule
phospho-p-Y204-MAPK3-3 [cytosol]
phospho-p-T202-MAPK3 [cytosol]
MAPK3 [nucleoplasm]
phospho-p-T202,Y204-MAPK3 [cytosol]
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
Inferred From
MAPK3 [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSBTAG00000016156
,
ENSBTAP00000021507
,
ENSBTAT00000021507
VGNC
31219
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