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MAPK1 [cytosol]
Stable Identifier
R-BTA-59282
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
P46196
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
L1CAM interactions (Bos taurus)
Signal transduction by L1 (Bos taurus)
MAP2K2 phosphorylates MAPK1 (Bos taurus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
F2R:ARRB1 binds MAPKs, SRC-1 (Bos taurus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
F2R:ARRB2 binds MAPKs, SRC-1 (Bos taurus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
SRC-1 bound to ARRB2 is not activated (Bos taurus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Bos taurus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Growth hormone receptor signaling (Bos taurus)
Lyn activates ERK (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon gamma signaling (Bos taurus)
IFNG signaling activates MAPKs (Bos taurus)
JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
MAPK monomers and dimers [cytosol] (Bos taurus)
MAPK1 dimer [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAPK1 (ERK2) activation (Bos taurus)
MAP2K2 binds MAPK1 (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAP2K2 phosphorylates MAPK1 (Bos taurus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
MAPK monomers and dimers [cytosol] (Bos taurus)
MAPK1 dimer [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
Signal attenuation (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)
MAPK3,(MAPK1) [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)
MAPK3,(MAPK1) [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
MAPKs [cytosol] (Bos taurus)
MAPK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P46196
Reference Genes
BioGPS Gene:327672
ENSEMBL:ENSBTAG00000010312
KEGG Gene (Bos taurus):327672
Monarch:327672
NCBI Gene:327672
Reference Transcript
RefSeq:NM_175793.2
Other Identifiers
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005524
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005813
GO:0005815
GO:0005819
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006468
GO:0006915
GO:0007010
GO:0007049
GO:0007166
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0023052
GO:0031410
GO:0031647
GO:0032872
GO:0035556
GO:0036211
GO:0043226
GO:0051493
GO:0070161
GO:0070849
GO:0072584
GO:0072686
GO:0090170
GO:0106310
GO:0140096
GO:2000641
Participates
as a component of
MAPK1 dimer [cytosol] (Bos taurus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Bos taurus)
as an input of
MAP2K2 binds MAPK1 (Bos taurus)
as a candidate of
MAPK3,(MAPK1) [cytosol] (Bos taurus)
as a member of
MAPKs [cytosol] (Bos taurus)
Other forms of this molecule
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
phospho-p-T185-MAPK1 [cytosol]
MAPK1 [nucleoplasm]
phospho-p-T185,Y187-MAPK1 [cytosol]
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
Inferred From
MAPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_786987.1
Ensembl
ENSBTAP00000013623
,
ENSBTAG00000010312
,
ENSBTAT00000013623
VGNC
31212
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