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CASP8 [cytosol]
Stable Identifier
R-BTA-57031
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
CASP8(1-479), Q2LGB8
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TRIF-mediated programmed cell death (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
CASP8 [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TLR4-induced ripoptosome assembly (Bos taurus)
CASP8 [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Caspase activation via extrinsic apoptotic signalling pathway (Bos taurus)
Caspase activation via Death Receptors in the presence of ligand (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
CASP8 [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
Dimerization of procaspase-8 (Bos taurus)
FAS-mediated dimerization of procaspase-8 (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Bos taurus)
procaspase-8 dimer [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TNF-mediated dimerization of procaspase-8 (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Bos taurus)
procaspase-8 dimer [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TRAIL-mediated dimerization of procaspase-8 (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Bos taurus)
procaspase-8 dimer [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
Regulation by c-FLIP (Bos taurus)
Caspase-8 and FLIP(L) processing at DISC (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Bos taurus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
CASP8 activity is inhibited (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FLIP(S) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
FasL/ CD95L signaling (Bos taurus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
CASP8 [cytosol] (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
OPTN binds CASP8 (Bos taurus)
CASP8 [cytosol] (Bos taurus)
OPTN:CASP8 [cytosol] (Bos taurus)
CASP8 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q2LGB8
Gene Names
CASP8
Reference Genes
BioGPS Gene:507481 CASP8
ENSEMBL:ENSBTAG00000015718.5
KEGG Gene (Bos taurus):507481 CASP8
Monarch:507481 CASP8
NCBI Gene:507481 CASP8
Reference Transcript
RefSeq:XM_005202615.3 CASP8
RefSeq:NM_001045970.2 CASP8
Other Identifiers
507481
GO:0002376
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008233
GO:0008234
GO:0008625
GO:0012501
GO:0016787
GO:0023052
GO:0030154
GO:0030163
GO:0030225
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043123
GO:0043124
GO:0043226
GO:0045651
GO:0045862
GO:0048856
GO:0051603
GO:0051604
GO:0060546
GO:0071260
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097342
GO:0110165
GO:0140096
Participates
as a component of
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
OPTN:CASP8 [cytosol] (Bos taurus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
procaspase-8 dimer [cytosol] (Bos taurus)
as an input of
OPTN binds CASP8 (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
FAS-mediated dimerization of procaspase-8 (Bos taurus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)
TRAIL-mediated dimerization of procaspase-8 (Bos taurus)
TNF-mediated dimerization of procaspase-8 (Bos taurus)
TLR4-induced ripoptosome assembly (Bos taurus)
Other forms of this molecule
CASP8 [cytosol]
CASP8 [mitochondrial outer membrane]
CASP8 [mitochondrial outer membrane]
CASP8 [cytosol]
CASP8 [cytosol]
Inferred From
CASP8(1-479) [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005202672.1
,
NP_001039435.1
OpenTargets
ENSG00000064012
Ensembl
ENSBTAP00000038128
,
ENSBTAT00000075852
,
ENSBTAT00000038313
,
ENSBTAP00000062824
,
ENSBTAG00000015718
VGNC
26784
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