Reactome | USO1 [cytosol]

USO1 [cytosol]

Stable Identifier

R-BTA-5685737

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

USO1, P41541

Locations in the PathwayBrowser

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Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Asparagine N-linked glycosylation (Bos taurus)
    - Transport to the Golgi and subsequent modification (Bos taurus)
      - ER to Golgi Anterograde Transport (Bos taurus)
        
        COPI-mediated anterograde transport (Bos taurus)
        
        ARFGAPs stimulate ARF GTPase activity (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        Active ARF recruits coatomer (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        GBF1 stimulates ARF nucleotide exchange (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP recruits GBF1 to the ERGIC (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        COPII-mediated vesicle transport (Bos taurus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - ER to Golgi Anterograde Transport (Bos taurus)
    - COPI-mediated anterograde transport (Bos taurus)
      - ARFGAPs stimulate ARF GTPase activity (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
      - Active ARF recruits coatomer (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
      - GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
      - GBF1 stimulates ARF nucleotide exchange (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
      - RAB1:GTP recruits GBF1 to the ERGIC (Bos taurus)
        
        RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
    - COPII-mediated vesicle transport (Bos taurus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)
        
        USO1 homodimer [cytosol] (Bos taurus)
        
        USO1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:P41541

Gene Names

USO1

Reference Genes

BioGPS Gene:317724 USO1

ENSEMBL:ENSBTAG00000017028

ENSEMBL:ENSBTAG00000017028.6 USO1

KEGG Gene (Bos taurus):317724 USO1

Monarch:317724 USO1

NCBI Gene:317724 USO1

Reference Transcript

RefSeq:NM_174845.2 USO1

Other Identifiers

317724

GO:0000139

GO:0005515

GO:0005737

GO:0005794

GO:0006886

GO:0016192

GO:0043226

GO:0048280

GO:0061024

Participates

as a component of

USO1 homodimer [cytosol] (Bos taurus)

Other forms of this molecule

USO1 [transport vesicle]

USO1 [ER to Golgi transport vesicle membrane]

USO1 [Golgi membrane]

Inferred From

USO1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_777270.2

OpenTargets

ENSG00000138768

Ensembl

ENSBTAT00000022642, ENSBTAG00000017028, ENSBTAP00000022642

VGNC

36708

PDB

3GQ2, 3GRL

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