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RBBP8 homotetramer [nucleoplasm]
Stable Identifier
R-BTA-5684097
Type
Complex
Species
Bos taurus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Bos taurus)
DNA Double-Strand Break Repair (Bos taurus)
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
Processing of DNA double-strand break ends (Bos taurus)
CDK2 phosphorylates RBBP8 (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
MRN complex binds CDK2 and RBBP8 (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
SIRT6 deacetylates RBBP8 (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
HDR through MMEJ (alt-NHEJ) (Bos taurus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
LIG3 ligates remaining SSBs in MMEJ (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
MRN complex binds RBBP8 (Bos taurus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
RBBP8 homotetramer [nucleoplasm] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 4
RBBP8 [nucleoplasm]
(Bos taurus)
Participates
as an output of
LIG3 ligates remaining SSBs in MMEJ (Bos taurus)
SIRT6 deacetylates RBBP8 (Bos taurus)
as a component of
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Bos taurus)
as an input of
MRN complex binds RBBP8 (Bos taurus)
MRN complex binds CDK2 and RBBP8 (Bos taurus)
Inferred From
RBBP8 homotetramer [nucleoplasm]
(Homo sapiens)
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