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p-2S MAP2K homo/heterodimers [cytosol]
Stable Identifier
R-BTA-5672721
Type
Set [DefinedSet]
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
RAF activation (Bos taurus)
Phosphorylation of RAF (Bos taurus)
RAF activating kinases [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
Participants
members
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
p-S218,S222 MAP2K1 dimer [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
Participant Of
hasComponent
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane]
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane]
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane]
hasCandidate
RAF activating kinases [plasma membrane]
Inferred From
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
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