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NEIL1 [nucleoplasm]
Stable Identifier
R-BTA-5649648
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
NEIL1, F1MGF3
Locations in the PathwayBrowser
Expand all
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Base-Excision Repair, AP Site Formation (Bos taurus)
Depyrimidination (Bos taurus)
Cleavage of the damaged pyrimidine (Bos taurus)
NEIL1 cleaves DHU from damaged DNA (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:AP-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:DHU-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1 cleaves FapyA from damaged DNA (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:AP-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:FapyA-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1 cleaves FapyG from damaged DNA (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:AP-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:FapyG-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1 cleaves thymine glycol from damaged DNA (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:AP-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:Tg-dsDNA [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Bos taurus)
NEIL1 translocates to the nucleus (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Bos taurus)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 incises DNA strand 5' to the AP site (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 recruits POLB to incised AP site (Bos taurus)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
NEIL1 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MGF3
Gene Names
NEIL1
Reference Genes
ENSEMBL:ENSBTAG00000007365.6
ENSEMBL:ENSBTAG00000007365.7 NEIL1
Other Identifiers
513458
GO:0003676
GO:0003677
GO:0003684
GO:0003824
GO:0003906
GO:0005634
GO:0005654
GO:0005737
GO:0006281
GO:0006284
GO:0006974
GO:0006979
GO:0008152
GO:0008270
GO:0016787
GO:0016798
GO:0016799
GO:0016829
GO:0019104
GO:0043226
GO:0140078
GO:0140097
Participates
as a member of
NEIL1,NEIL2 [nucleoplasm] (Bos taurus)
as a component of
NEIL1:FapyA-dsDNA [nucleoplasm] (Bos taurus)
NEIL1:FapyG-dsDNA [nucleoplasm] (Bos taurus)
NEIL1:Tg-dsDNA [nucleoplasm] (Bos taurus)
NEIL1:AP-dsDNA [nucleoplasm] (Bos taurus)
NEIL1:DHU-dsDNA [nucleoplasm] (Bos taurus)
as an output of
NEIL1 translocates to the nucleus (Bos taurus)
Other forms of this molecule
NEIL1 [cytosol]
Inferred From
NEIL1 [nucleoplasm]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000140398
Ensembl
ENSBTAG00000007365
,
ENSBTAT00000052162
,
ENSBTAP00000050077
,
ENSBTAT00000046326
,
ENSBTAP00000043635
VGNC
31988
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