Reactome | IQCB1 [cytosol]

IQCB1 [cytosol]

Stable Identifier

R-BTA-5626648

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

IQCB1, Q29RS3

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Bos taurus)

- Cilium Assembly (Bos taurus)
  - Anchoring of the basal body to the plasma membrane (Bos taurus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
    - C2CD3 binds the mother centriole (Bos taurus)
      - mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
    - CP110 and CEP97 dissociate from the centriole (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
    - MARK4 binds ODF2 in the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
    - Recruitment of transition zone proteins (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
    - The distal appendage proteins recruit TTBK2 (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        IQCB1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q29RS3

Gene Names

IQCB1

Reference Genes

BioGPS Gene:534598 IQCB1

ENSEMBL:ENSBTAG00000013069.4

KEGG Gene (Bos taurus):534598 IQCB1

Monarch:534598 IQCB1

NCBI Gene:534598 IQCB1

Reference Transcript

Other Identifiers

534598

GO:0001750

GO:0005515

GO:0005516

GO:0005634

GO:0005654

GO:0005813

GO:0005815

GO:0005856

GO:0005929

GO:0015630

GO:0019899

GO:0030154

GO:0032391

GO:0043226

GO:0044782

GO:0045171

GO:0045494

GO:0048496

GO:0048856

GO:0060271

GO:0072686

Participates

as a component of

Inferred From

IQCB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001039846.1, XP_010799478.1

OpenTargets

ENSG00000173226

Ensembl

ENSBTAP00000017379, ENSBTAT00000017379, ENSBTAG00000013069

VGNC

30250