Reactome | GNAQ [plasma membrane]

GNAQ [plasma membrane]

Stable Identifier

R-BTA-55453

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

GNAQ, E1BA29

Locations in the PathwayBrowser

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Hemostasis (Bos taurus)

- Platelet activation, signaling and aggregation (Bos taurus)
  - Signal amplification (Bos taurus)
    - ADP signalling through P2Y purinoceptor 1 (Bos taurus)
      - Dissociation of the P2Y purinoceptor 1:Gq complex (Bos taurus)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
    - Thromboxane signalling through TP receptor (Bos taurus)
      - Activated TP receptor binds G-proten Gq (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
      - Dissociation of the TP:Gq complex (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
      - Gq activation by TP receptor (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
  - Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
    - Thrombin-activated PARs activate Gq (Bos taurus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
    - Thrombin-activated PARs binds G-protein Gq (Bos taurus)
      - Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
    - Thrombin-activated PARs:Gq (active) dissociate (Bos taurus)
      - G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNAQ [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BA29

Gene Names

GNAQ

Reference Genes

BioGPS Gene:536654 GNAQ

ENSEMBL:ENSBTAG00000009789.6

KEGG Gene (Bos taurus):536654 GNAQ

Monarch:536654 GNAQ

NCBI Gene:536654 GNAQ

Reference Transcript

RefSeq:NM_001110002.1 GNAQ

Other Identifiers

536654

GO:0000166

GO:0001508

GO:0001664

GO:0001750

GO:0003824

GO:0003924

GO:0005096

GO:0005525

GO:0005834

GO:0005886

GO:0005929

GO:0007165

GO:0007186

GO:0007189

GO:0007213

GO:0007215

GO:0007603

GO:0009649

GO:0016020

GO:0016787

GO:0019001

GO:0023052

GO:0031683

GO:0043226

GO:0045202

GO:0060158

GO:0098772

Participates

as a candidate of

G(q) alpha 11,14,15,Q [plasma membrane] (Bos taurus)

as a member of

G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)

Inferred From

GNAQ [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001103472.1

OpenTargets

ENSG00000156052

Ensembl

ENSBTAT00000016160, ENSBTAG00000009789, ENSBTAP00000016160

VGNC

29453

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