Reactome | FEN1 [nucleoplasm]

FEN1 [nucleoplasm]

Stable Identifier

R-BTA-54745

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

Q58DH8

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle, Mitotic (Bos taurus)
  - S Phase (Bos taurus)
    - Synthesis of DNA (Bos taurus)
      - DNA strand elongation (Bos taurus)
        
        Lagging Strand Synthesis (Bos taurus)
        
        Processive synthesis on the lagging strand (Bos taurus)
        
        Removal of the Flap Intermediate (Bos taurus)
        
        Removal of remaining Flap (Bos taurus)
        
        FEN1 [nucleoplasm] (Bos taurus)
- Chromosome Maintenance (Bos taurus)
  - Telomere Maintenance (Bos taurus)
    - Extension of Telomeres (Bos taurus)
      - Telomere C-strand (Lagging Strand) Synthesis (Bos taurus)
        
        Processive synthesis on the C-strand of the telomere (Bos taurus)
        
        Removal of the Flap Intermediate from the C-strand (Bos taurus)
        
        Removal of remaining Flap from the C-strand (Bos taurus)
        
        FEN1 [nucleoplasm] (Bos taurus)

DNA Replication (Bos taurus)

- Synthesis of DNA (Bos taurus)
  - DNA strand elongation (Bos taurus)
    - Lagging Strand Synthesis (Bos taurus)
      - Processive synthesis on the lagging strand (Bos taurus)
        
        Removal of the Flap Intermediate (Bos taurus)
        
        Removal of remaining Flap (Bos taurus)
        
        FEN1 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q58DH8

Reference Genes

BioGPS Gene:616242

ENSEMBL:ENSBTAG00000000064

ENSEMBL:ENSBTAG00000000064.5

KEGG Gene (Bos taurus):616242

Monarch:616242

NCBI Gene:616242

Reference Transcript

RefSeq:NM_001035113.1

Other Identifiers

616242

GO:0000781

GO:0003677

GO:0003824

GO:0004523

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005739

GO:0006260

GO:0008409

GO:0016787

GO:0017108

GO:0032991

GO:0043137

GO:0043226

GO:0045876

GO:0048256

GO:0090304

GO:0140097

GO:0140098

Participates

as an input of

as a component of

as an output of

FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)

Inferred From

FEN1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001030285.1

Ensembl

ENSBTAT00000000071, ENSBTAG00000000064, ENSBTAP00000000071

VGNC

28947