Reactome | MTIF3 binds 28S ribosomal subunit

MTIF3 binds 28S ribosomal subunit

Stable Identifier

R-BTA-5432456

Type

Reaction [binding]

Species

Bos taurus

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

General

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MTIF3 (IF3mt) binds the 28S ribosomal subunit in preparation for binding mRNA and initiating translation (Haque and Spremulli 2008, Haque et al. 2008, Christian et al. 2010, Haque et al 2011). MTIF3 also dissociates 55S particles that have not already been dissociated by GFM2 plus MRRF and displaces N-formylmethionyl-tRNA from the 28S subunit in the absence of mRNA but cannot displace mRNA from the 28S subunit (Bhargava and Spremulli 2005). The activity of MTIF3 is necessary for translation initiation (Koc and Spremulli 2002, Christian and Spremulli 2009). The 28S subunit associates with the matrix-side face of the inner mitochondrial membrane and translation products are inserted directly into the membrane (Liu and Spremulli 2000).

Literature References

PubMed ID	Title	Journal	Year
19239245	Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria Spremulli, LL, Christian, BE	Biochemistry	2009
22015679	Contacts between mammalian mitochondrial translational initiation factor 3 and ribosomal proteins in the small subunit Cimen, H, Spremulli, LL, Koc, EC, Haque, ME, Koc, H	Biochim. Biophys. Acta	2011
16340009	Role of the N- and C-terminal extensions on the activity of mammalian mitochondrial translational initiation factor 3 Spremulli, LL, Bhargava, K	Nucleic Acids Res.	2005
12095986	Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs Spremulli, LL, Koc, EC	J. Biol. Chem.	2002
19962967	The effect of spermine on the initiation of mitochondrial protein synthesis Spremulli, LL, Haque, ME, Christian, BE	Biochem. Biophys. Res. Commun.	2010
10887179	Interaction of mammalian mitochondrial ribosomes with the inner membrane Liu, M, Spremulli, L	J. Biol. Chem.	2000
18056078	The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3mt Spremulli, LL, Grasso, D, Haque, ME	Nucleic Acids Res.	2008
18930736	Roles of the N- and C-terminal domains of mammalian mitochondrial initiation factor 3 in protein biosynthesis Spremulli, LL, Haque, ME	J. Mol. Biol.	2008

Participants

Input

Output

28S ribosomal subunit:MTIF3 [mitochondrial inner membrane] (Bos taurus)

Orthologous Events

MTIF3 binds 28S ribosomal subunit (Homo sapiens)

Authored

May, B (2014-05-09)

Reviewed

Chrzanowska-Lightowlers, ZM (2014-08-29)

Spremulli, LL (2014-09-20)

Created

May, B (2014-05-11)

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