Reactome | phospho-SHB [cytosol]

phospho-SHB [cytosol]

Stable Identifier

R-BTA-5228991

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

pS-SHB, E1BLY9

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by VEGF (Bos taurus)
    - VEGFA-VEGFR2 Pathway (Bos taurus)
      - Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - CRK binds BCAR1 and or PXN (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - DOCK180:ELMO binds CRK (Bos taurus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - HSP90AA1 binds p-6Y-VEGFR2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - PTK2 autophosphorylates (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - PXN binds p-6Y,S732-PTK2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - SRC-1 binds p-Y397-PTK2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - SRC-1 phosphorylates PTK2-beta (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - SRC-1 phosphorylates SHB (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - Src kinases phosphorylate VAV (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
      - p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)
        
        phospho-SHB [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BLY9

Gene Names

SHB

Reference Genes

BioGPS Gene:538275 SHB

ENSEMBL:ENSBTAG00000014922.6

KEGG Gene (Bos taurus):538275 SHB

Monarch:538275 SHB

NCBI Gene:538275 SHB

Reference Transcript

RefSeq:NM_001192934.2 SHB

Other Identifiers

538275

GO:0001784

Participates

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Bos taurus)

Other forms of this molecule

SHB [cytosol]

Inferred From

pS-SHB [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001179863.1

OpenTargets

ENSG00000107338

Ensembl

ENSBTAP00000034182, ENSBTAG00000014922, ENSBTAT00000034285

VGNC

34588

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