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phospho-MLKL [cytosol]
Stable Identifier
R-BTA-5218903
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
p-T357,S358-MLKL, E1BGC6
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
MLKL binds PIPs (Bos taurus)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
RIPK3 phosphorylates MLKL (Bos taurus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
ITCH polyubiquitinates MLKL at K50 (Bos taurus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
MLKL binds FLOT1, FLOT2 (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
MLKL binds IP4, IP5 and IP6 (Bos taurus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Bos taurus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
MLKL binds ITCH (Bos taurus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
MLKL binds PDCD6IP and SDCBP (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Stimuli-sensing channels (Bos taurus)
TRP channels (Bos taurus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
TRPs transport extracellular Ca2+ to cytosol (Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
phospho-MLKL [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BGC6
Gene Names
MLKL
Reference Genes
BioGPS Gene:790225 MLKL
ENSEMBL:ENSBTAG00000012216.6
KEGG Gene (Bos taurus):790225 MLKL
Monarch:790225 MLKL
NCBI Gene:790225 MLKL
Reference Transcript
RefSeq:XM_005218382.3 MLKL
RefSeq:XM_001256759.6 MLKL
RefSeq:XM_005195172.3 MLKL
RefSeq:XM_005218381.3 MLKL
RefSeq:XM_002694707.5 MLKL
RefSeq:XM_010814341.2 MLKL
RefSeq:XM_010823507.2 MLKL
RefSeq:XM_005195171.3 MLKL
Other Identifiers
790225
GO:0003824
GO:0004672
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007166
GO:0012501
GO:0016740
GO:0019901
GO:0023052
GO:0030054
GO:0036211
GO:0043226
GO:0044877
GO:0051607
GO:0065003
GO:0070207
GO:0070266
GO:0097527
GO:0097528
GO:0098542
GO:0140096
Participates
as a repeated unit of
p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
as a component of
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
Other forms of this molecule
phospho-MLKL [cytosol]
MLKL [cytosol]
Inferred From
p-T357,S358-MLKL [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 358 (in Homo sapiens)
Coordinate
358
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 357 (in Homo sapiens)
Coordinate
357
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_002694753.1
,
XP_001256760.1
,
XP_005218439.1
,
XP_005195229.1
,
XP_005218438.1
,
XP_010812643.1
,
XP_005195228.1
,
XP_010821809.1
OpenTargets
ENSG00000168404
Ensembl
ENSBTAP00000056914
,
ENSBTAT00000082389
,
ENSBTAP00000016202
,
ENSBTAG00000012216
,
ENSBTAT00000016202
VGNC
31500
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