Reactome | phospho-PXN [cytosol]

phospho-PXN [cytosol]

Stable Identifier

R-BTA-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

p-Y31,Y118-PXN, F1MFD1

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by PTK6 (Bos taurus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Bos taurus)
      - Activation of RAC1 by the PXN:CRK complex (Bos taurus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
      - PTK6 phosphorylates PXN (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
      - Phosphorylated PXN recruits the CRK complex (Bos taurus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by VEGF (Bos taurus)
    - VEGFA-VEGFR2 Pathway (Bos taurus)
      - CRK binds BCAR1 and or PXN (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
      - DOCK180:ELMO binds CRK (Bos taurus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        phospho-PXN [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MFD1

Gene Names

PXN

Reference Genes

ENSEMBL:ENSBTAG00000018108.6

ENSEMBL:ENSBTAG00000018108.7 PXN

Other Identifiers

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0007155

GO:0007179

GO:0023052

GO:0034446

GO:0043226

GO:0043542

GO:0046872

GO:0048870

Participates

as a component of

as an input of

Phosphorylated PXN recruits the CRK complex (Bos taurus)

as an output of

PTK6 phosphorylates PXN (Bos taurus)

Other forms of this molecule

PXN [plasma membrane]

phospho-PXN [plasma membrane]

PXN [cytosol]

Inferred From

p-Y31,Y118-PXN [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31 (in Homo sapiens)

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118 (in Homo sapiens)

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000089159

Ensembl

ENSBTAT00000024101, ENSBTAG00000018108, ENSBTAP00000024101

VGNC

107261