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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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Our Logo
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Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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JAK3 [cytosol]
Stable Identifier
R-BTA-451893
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
E1BEL4
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylated SHC1 recruits SHIP (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-15 signaling (Bos taurus)
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Bos taurus)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-2 signaling (Bos taurus)
IL2RG binds JAK3 (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Bos taurus)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 binds JAK3 inhibitors (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
PTK2B binds JAK3 (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:PYK2 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
PTK2B is phosphorylated (Bos taurus)
JAK3:PYK2 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:p-PYK2 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylated STAT5 is released (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Recruited STAT5 is phosphorylated (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
SYK binds IL2RB (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
SYK is a substrate for JAK1 (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-21 signaling (Bos taurus)
IL21 receptor JAK phosphorylation (Bos taurus)
IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL21:IL21R:JAK1 binds IL2RG:JAK3 (Bos taurus)
IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-9 signaling (Bos taurus)
IL2RG binds JAK3 (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Bos taurus)
IL9:IL9R:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 binds JAK3 inhibitors (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-20 family signaling (Bos taurus)
IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Bos taurus)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Bos taurus)
JAK2, JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK2, JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Bos taurus)
JAK2, JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Phosphorylated SHC1 recruits SHIP (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-4 and Interleukin-13 signaling (Bos taurus)
IL2RG binds JAK3 (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Bos taurus)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK1 binds IL4R in IL4-bound IL4R1 (Bos taurus)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Bos taurus)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK1 phosphorylates STAT3,STAT6 (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 binds JAK3 inhibitors (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
STAT3,STAT6 bind p-Y-IL4R (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Bos taurus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Interleukin-7 signaling (Bos taurus)
IL2RG binds JAK3 (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL7:IL7R:JAK1 binds IL2RG:JAK3 (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 binds JAK3 inhibitors (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)
IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
Active ALK binds JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
Active ALK phosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
PTPN6 dephosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
JAK3 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BEL4
Reference Genes
BioGPS Gene:538276
ENSEMBL:ENSBTAG00000020904.6
ENSEMBL:ENSBTAG00000020904.7
KEGG Gene (Bos taurus):538276
Monarch:538276
NCBI Gene:538276
Reference Transcript
RefSeq:XM_015471919.1
RefSeq:XM_015463951.1
RefSeq:XM_015463952.1
RefSeq:XM_010806603.2
RefSeq:XM_010806605.2
RefSeq:XM_010798159.2
RefSeq:XM_010798161.2
RefSeq:XM_015471920.1
Other Identifiers
GO:0000166
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005524
GO:0005829
GO:0005856
GO:0005886
GO:0007259
GO:0012501
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019903
GO:0023052
GO:0030154
GO:0031234
GO:0035556
GO:0035723
GO:0035771
GO:0036211
GO:0038110
GO:0038113
GO:0042981
GO:0043226
GO:0060397
GO:0070670
GO:0140096
Participates
as a candidate of
JAK2, JAK3 [cytosol] (Bos taurus)
as an input of
Active ALK binds JAK3 (Bos taurus)
PTK2B binds JAK3 (Bos taurus)
JAK3 binds JAK3 inhibitors (Bos taurus)
IL2RG binds JAK3 (Bos taurus)
as a component of
Active ALK:JAK3 [plasma membrane] (Bos taurus)
JAK3:p-PYK2 [cytosol] (Bos taurus)
JAK3:PYK2 [cytosol] (Bos taurus)
p-Y-IL2RG:JAK3 [plasma membrane] (Bos taurus)
JAK3:JAK3 inhibitors [cytosol] (Bos taurus)
IL2RG:JAK3 [plasma membrane] (Bos taurus)
Other forms of this molecule
phospho-p-Y980 JAK3 [cytosol]
JAK3 [endosome]
phospho-p-Y904,939-JAK3 [plasma membrane]
phospho-p-Y-JAK3 [cytosol]
phospho-p-JAK3 [cytosol]
Inferred From
JAK3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_010804905.1
,
XP_010796463.1
,
XP_015327405.1
,
XP_015319437.1
,
XP_015327406.1
,
XP_015319438.1
,
XP_010804907.1
,
XP_010796461.1
Ensembl
ENSBTAP00000027857
,
ENSBTAG00000020904
,
ENSBTAT00000027857
VGNC
30366
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