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IKBKE [cytosol]
Stable Identifier
R-BTA-450225
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
F1MQ36
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Bos taurus)
IKBKE:IKBKE [cytosol] (Bos taurus)
IKBKE [cytosol] (Bos taurus)
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
Negative regulators of DDX58/IFIH1 signaling (Bos taurus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)
TAX1BP1:TNFAIP3:TBK1/IKBKE [cytosol] (Bos taurus)
TBK1, IKBKE [cytosol] (Bos taurus)
IKBKE [cytosol] (Bos taurus)
TBK1, IKBKE [cytosol] (Bos taurus)
IKBKE [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Bos taurus)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
IKBKE:IKBKE [cytosol] (Bos taurus)
IKBKE [cytosol] (Bos taurus)
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
IKBKE [cytosol] (Bos taurus)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
IKBKE:IKBKE [cytosol] (Bos taurus)
IKBKE [cytosol] (Bos taurus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Bos taurus)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Bos taurus)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
IKBKE:IKBKE [cytosol] (Bos taurus)
IKBKE [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TBK1, IKBKE [cytosol] (Bos taurus)
IKBKE [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MQ36
Reference Genes
ENSEMBL:ENSBTAG00000010408.6
ENSEMBL:ENSBTAG00000010408.7
Other Identifiers
533216
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0006955
GO:0008384
GO:0008630
GO:0010467
GO:0010884
GO:0012501
GO:0016071
GO:0016605
GO:0016740
GO:0023052
GO:0031625
GO:0031966
GO:0032481
GO:0034340
GO:0035456
GO:0036211
GO:0036435
GO:0042802
GO:0043123
GO:0043226
GO:0043254
GO:0048255
GO:0060340
GO:0065003
GO:0097400
GO:0098542
GO:0098586
GO:0140096
Participates
as an input of
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
as a component of
IKBKE:IKBKE [cytosol] (Bos taurus)
as a member of
TBK1, IKBKE [cytosol] (Bos taurus)
Other forms of this molecule
phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
phospho-p-S172-IKBKE [nucleoplasm]
K63polyUb-K30,K401-IKBKE [cytosol]
phospho-p-S172-IKBKE [cytosol]
Inferred From
IKBKE [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSBTAT00000013738
,
ENSBTAP00000013738
,
ENSBTAG00000010408
VGNC
30101
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