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NUMB [plasma membrane]
Stable Identifier
R-BTA-443595
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
NUMB, E1B8G1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
Degradation of GLI1 by the proteasome (Bos taurus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB binds ITCH (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH bind and ubiquitnate GLI1 (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
Hedgehog 'on' state (Bos taurus)
NUMB binds ITCH (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH binds GLI1 (Bos taurus)
GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
NUMB:ITCH ubiquitinates GLI1 (Bos taurus)
GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
ub-GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
ub-GLI is degraded by the proteasome (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
ub-GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
NUMB [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:E1B8G1
Gene Names
NUMB
Reference Genes
ENSEMBL:ENSBTAG00000011683.6
UCSC:E1B8G1 NUMB
Other Identifiers
GO:0005768
GO:0005769
GO:0005905
GO:0007399
GO:0007405
GO:0007409
GO:0008013
GO:0016323
GO:0021670
GO:0021849
GO:0030136
GO:0030335
GO:0030900
GO:0031410
GO:0034330
GO:0034332
GO:0043226
GO:0045177
GO:0045294
GO:0045296
GO:0048856
GO:0050769
GO:0098978
GO:0099149
GO:1903077
Participates
as an input of
NUMB binds ITCH (Bos taurus)
as a component of
NUMB:ITCH [cytosol] (Bos taurus)
Inferred From
NUMB [plasma membrane]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAG00000011683
,
ENSBTAT00000052258
,
ENSBTAP00000052600
VGNC
50234
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