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Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D
Stable Identifier
R-BTA-391520
Type
Reaction [binding]
Species
Bos taurus
Compartment
cytosol
ReviewStatus
5/5
General
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Beta-tubulin folding intermediates generated via ATP-dependent interaction with TriC/CCT are captured by tubulin-specific chaperones A and D (TBCA and TBCD) (Tian et al. 1996, Tian et al. 1997) in a reversible reaction forming tubulin intermediate/cofactor complexes Factor A:beta tubulin or Factor D:beta tubulin. TBCD is involved in the tubulin-folding pathway, acting as a GTPase activating protein (GAP) for beta-tubulin. The ADP-ribosylation factor-like protein 2 (ARL2) is able to down-regulate TBCD specifically, thus preventing microtuble disruption (Bhamidipati et al. 2000, Tian et al. 2010).
Literature References
PubMed ID
Title
Journal
Year
9265649
Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors
Rommelaere, H
,
Lewis, SA
,
Stearns, T
,
Cowan, NJ
,
Feierbach, B
,
Tian, G
,
Ampe, C
J Cell Biol
1997
Participants
Input
GTP:beta-tubulin folding intermediate [cytosol]
(Bos taurus)
Tubulin-specific chaperone D [cytosol]
(Bos taurus)
Output
Cofactor D:GTP:beta tubulin [cytosol]
(Bos taurus)
Orthologous Events
Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D (Homo sapiens)
Authored
Cowan, NJ (2009-01-21)
Reviewed
Cowan, NJ (2009-01-21)
Created
Matthews, L (2009-02-23)
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