alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E

Stable Identifier
R-BTA-391519
Type
Reaction [binding]
Species
Bos taurus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E
Quasi-native alpha-tubulin folding intermediates generated via ATP-dependent interaction with CCT (Tian et al., 1995) are captured in a reversible reaction by cofactors B and/or E (Tian et al., 1997), forming the tubulin intermediate/cofactor complexes Factor B:alpha tubulin or Factor E:alpha tubulin.
Literature References
PubMed ID Title Journal Year
9265649 Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors

Rommelaere, H, Lewis, SA, Stearns, T, Cowan, NJ, Feierbach, B, Tian, G, Ampe, C

J Cell Biol 1997
Participants
Input
Output
Orthologous Events
alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Authored
Cowan, NJ  (2009-01-21)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-02-23)
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