Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A

Stable Identifier
R-BTA-391517
Type
Reaction [transition]
Species
Bos taurus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A
Factor A:beta tubulin complex act as a reservoir capable of accepting or delivering its target tubulin protein to cofactor D (Tian et al., 1997). In the reverse reaction, Cofactor A may displace cofactor D in a cofactor D:beta tubulin complex.
Literature References
PubMed ID Title Journal Year
9265649 Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors

Rommelaere, H, Lewis, SA, Stearns, T, Cowan, NJ, Feierbach, B, Tian, G, Ampe, C

J Cell Biol 1997
Participants
Input
Output
Orthologous Events
Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A (Homo sapiens)
Authored
Cowan, NJ  (2009-01-21)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-02-23)
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