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VHL [cytosol]
Stable Identifier
R-BTA-391423
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
VHL, E1BL53
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
VHL [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
VBC complex (with or without LIMD1) [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
26S proteasome degrades HIFalpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
VBC complex [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)
RHOBTB3 interacting proteins [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Bos taurus)
RHOBTB3 interacting proteins [cytosol] (Bos taurus)
VHL [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BL53
Gene Names
VHL
Reference Genes
BioGPS Gene:540957 VHL
ENSEMBL:ENSBTAG00000016101.5
KEGG Gene (Bos taurus):540957 VHL
Monarch:540957 VHL
NCBI Gene:540957 VHL
Reference Transcript
RefSeq:NM_001110019.1 VHL
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Bos taurus)
CUL2-box protein [cytosol] (Bos taurus)
as a component of
VBC complex [cytosol] (Bos taurus)
Other forms of this molecule
VHL [nucleoplasm]
VHL [nucleoplasm]
Inferred From
VHL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001103489.1
OpenTargets
ENSG00000134086
VGNC
97325
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