Reactome | FBXW4 [cytosol]

FBXW4 [cytosol]

Stable Identifier

R-BTA-391305

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

FBXW4, A0A3S5ZPN9

Locations in the PathwayBrowser

Expand all

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXW4 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3S5ZPN9

Gene Names

FBXW4

Reference Genes

ENSEMBL:ENSBTAG00000003579.6

Other Identifiers

513977

GO:0005515

GO:0019005

GO:0030163

GO:0031146

Participates

as a member of

F-box protein [cytosol] (Bos taurus)

Inferred From

FBXW4 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000107829

Ensembl

ENSBTAP00000004657, ENSBTAT00000004657, ENSBTAG00000003579

VGNC

28924

Cite Us!