Reactome | SFTPA1 [extracellular region]

SFTPA1 [extracellular region]

Stable Identifier

R-BTA-391093

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

SFTPA1, A0A3Q1NJ66

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Bos taurus)

- Signal regulatory protein family interactions (Bos taurus)
  - SIRPA binds SFTPA oligomer, SFTPD oligomer (Bos taurus)
    - SFTPA oligomer, SFTPD oligomer [extracellular region] (Bos taurus)
      - SFTPA oligomer [extracellular region] (Bos taurus)
        
        SFTPA trimer [extracellular region] (Bos taurus)
        
        SFTPA1 [extracellular region] (Bos taurus)
    - SIRPA:SFTPA oligomer, SFTPD oligomer [plasma membrane] (Bos taurus)
      - SFTPA oligomer, SFTPD oligomer [extracellular region] (Bos taurus)
        
        SFTPA oligomer [extracellular region] (Bos taurus)
        
        SFTPA trimer [extracellular region] (Bos taurus)
        
        SFTPA1 [extracellular region] (Bos taurus)

Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - Toll-like Receptor Cascades (Bos taurus)
    - Regulation of TLR by endogenous ligand (Bos taurus)
      - SFTPA/SFTPD binds TLR4:LY96 (Bos taurus)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Bos taurus)
        
        SFTPA oligomer [extracellular region] (Bos taurus)
        
        SFTPA trimer [extracellular region] (Bos taurus)
        
        SFTPA1 [extracellular region] (Bos taurus)
        
        SP-A/SP-D:TLR4:MD2 [plasma membrane] (Bos taurus)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Bos taurus)
        
        SFTPA oligomer [extracellular region] (Bos taurus)
        
        SFTPA trimer [extracellular region] (Bos taurus)
        
        SFTPA1 [extracellular region] (Bos taurus)
    - Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
      - Transfer of LPS onto TLR4 (Bos taurus)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Bos taurus)
        
        SFTPA oligomer [extracellular region] (Bos taurus)
        
        SFTPA trimer [extracellular region] (Bos taurus)
        
        SFTPA1 [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1NJ66

Gene Names

SFTPA1

Reference Genes

ENSEMBL:ENSBTAG00000023032.5

UCSC:A0A3Q1NJ66 SFTPA1

Other Identifiers

407213

Bt.14581.1.A1_at

Bt.29876.1.S1_at

GO:0002376

GO:0005576

GO:0005581

GO:0005615

GO:0005768

GO:0005771

GO:0007585

GO:0030246

GO:0031410

GO:0043226

GO:0045087

GO:0098542

Participates

as a component of

SFTPA trimer [extracellular region] (Bos taurus)

Other forms of this molecule

SFTPA1 [lamellar body]

SFTPA1 [endoplasmic reticulum membrane]

SFTPA1 [clathrin-coated endocytic vesicle]

Inferred From

SFTPA [extracellular region] (Homo sapiens)

SFTPA2 [extracellular region] (Homo sapiens)

SFTPA1 [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSBTAP00000072149, ENSBTAT00000068360, ENSBTAG00000023032

© 2025 Reactome

Cite Us!