Reactome | CEP57 [cytosol]

CEP57 [cytosol]

Stable Identifier

R-BTA-380271

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

CEP57, A0A3Q1LT15

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Bos taurus)

- Cilium Assembly (Bos taurus)
  - Anchoring of the basal body to the plasma membrane (Bos taurus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
    - C2CD3 binds the mother centriole (Bos taurus)
      - mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
    - CP110 and CEP97 dissociate from the centriole (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
    - MARK4 binds ODF2 in the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
    - Recruitment of transition zone proteins (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
    - The distal appendage proteins recruit TTBK2 (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP57 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1LT15

Gene Names

CEP57

Reference Genes

ENSEMBL:ENSBTAG00000016547.6

Other Identifiers

353245

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0008017

GO:0008092

GO:0042802

GO:0043015

GO:0043226

Participates

as a component of

Inferred From

CEP57 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000166037

Ensembl

ENSBTAG00000016547, ENSBTAP00000058237, ENSBTAT00000073227

VGNC

27207

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