Reactome | PPP2R2A [cytosol]

PPP2R2A [cytosol]

Stable Identifier

R-BTA-377253

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

PPP2R2A, F1MG56

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle, Mitotic (Bos taurus)
  - M Phase (Bos taurus)
    - Mitotic Metaphase and Anaphase (Bos taurus)
      - Mitotic Anaphase (Bos taurus)
        
        Nuclear Envelope (NE) Reassembly (Bos taurus)
        
        Initiation of Nuclear Envelope (NE) Reformation (Bos taurus)
        
        ANKLE2 binds PP2A (Bos taurus)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Bos taurus)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
        
        PPP2R2A [cytosol] (Bos taurus)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
        
        PPP2R2A [cytosol] (Bos taurus)
        
        PP2A dephosphorylates BANF1 (Bos taurus)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Bos taurus)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
        
        PPP2R2A [cytosol] (Bos taurus)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
        
        PPP2R2A [cytosol] (Bos taurus)

Cellular responses to stimuli (Bos taurus)

- Cellular responses to mechanical stimuli (Bos taurus)
  - Response of endothelial cells to shear stress (Bos taurus)
    - Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
      - PP2A dephosphorylates serine-127 of YAP1 (Bos taurus)
        
        p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Bos taurus)
        
        PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Bos taurus)
        
        PPP2R2A [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MG56 PPP2R2A

Gene Names

PPP2R2A

Reference Genes

BioGPS Gene:508045 PPP2R2A

ENSEMBL:ENSBTAG00000018317.7 PPP2R2A

KEGG Gene (Bos taurus):508045 PPP2R2A

Monarch:508045 PPP2R2A

NCBI Gene:508045 PPP2R2A

Reference Transcript

RefSeq:NM_001191533.1 PPP2R2A

Other Identifiers

508045

GO:0000159

GO:0005829

GO:0019888

GO:0043278

GO:0045202

GO:0098772

GO:0098978

Participates

as a component of

Other forms of this molecule

PPP2R2A [cytosol]

PPP2R2A [nucleoplasm]

Inferred From

PPP2R2A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001178462.1

OpenTargets

ENSG00000221914

Ensembl

ENSBTAP00000024373, ENSBTAT00000024373, ENSBTAG00000018317

VGNC

33255