Reactome | ERCC6L [cytosol]

ERCC6L [cytosol]

Stable Identifier

R-BTA-376250

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

A6QQR4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - Mitotic Spindle Checkpoint (Bos taurus)
    - Amplification of signal from the kinetochores (Bos taurus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Bos taurus)
        
        MAD2 associates with the Mad1 kinetochore complex (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Mad1 binds kinetochore (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Release of activated MAD2 from kinetochores (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
- Cell Cycle, Mitotic (Bos taurus)
  - M Phase (Bos taurus)
    - Mitotic Metaphase and Anaphase (Bos taurus)
      - Mitotic Anaphase (Bos taurus)
        
        Separation of Sister Chromatids (Bos taurus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Separation of sister chromatids (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
    - Mitotic Prometaphase (Bos taurus)
      - EML4 and NUDC in mitotic spindle formation (Bos taurus)
        
        EML4 recruits NUDC to mitotic spindle (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
      - Kinetochore capture of astral microtubules (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
      - Resolution of Sister Chromatid Cohesion (Bos taurus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Kinetochore assembly (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        ERCC6L [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A6QQR4

Reference Genes

BioGPS Gene:782916

ENSEMBL:ENSBTAG00000005607

ENSEMBL:ENSBTAG00000005607.6

KEGG Gene (Bos taurus):782916

Monarch:782916

NCBI Gene:782916

Reference Transcript

RefSeq:NM_001102530.2

Other Identifiers

782916

GO:0003824

GO:0005524

GO:0006325

GO:0015616

GO:0140097

GO:0140657

GO:0140658

Participates

as a component of

Kinetochore [cytosol] (Bos taurus)

Inferred From

ERCC6L [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001096000.1

Ensembl

ENSBTAT00000007362, ENSBTAG00000005607, ENSBTAP00000007362

VGNC

28573

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