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P4HB [endoplasmic reticulum lumen]
Stable Identifier
R-BTA-3341287
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
endoplasmic reticulum lumen
Synonyms
HC53,56-P4HB, F6Q9Q9
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)
P4HB [endoplasmic reticulum lumen] (Bos taurus)
Metabolism of proteins (Bos taurus)
Peptide hormone metabolism (Bos taurus)
Insulin processing (Bos taurus)
ERO1B oxidizes P4HB (Bos taurus)
P4HB [endoplasmic reticulum lumen] (Bos taurus)
P4HB mediates disulfide bond formation in Proinsulin (Bos taurus)
P4HB [endoplasmic reticulum lumen] (Bos taurus)
External Reference Information
External Reference
UniProt:F6Q9Q9
Gene Names
P4HB
Reference Genes
ENSEMBL:ENSBTAG00000006045.5
ENSEMBL:ENSBTAG00000006045.6 P4HB
Other Identifiers
GO:0003756
GO:0003779
GO:0003824
GO:0004656
GO:0005178
GO:0005783
GO:0005788
GO:0005793
GO:0005829
GO:0005856
GO:0005886
GO:0006457
GO:0006888
GO:0007155
GO:0008092
GO:0009897
GO:0012501
GO:0015035
GO:0016020
GO:0016192
GO:0016222
GO:0016491
GO:0016853
GO:0016972
GO:0023052
GO:0030027
GO:0030070
GO:0031410
GO:0032991
GO:0034663
GO:0034975
GO:0034976
GO:0042470
GO:0043226
GO:0045785
GO:0046598
GO:0046982
GO:0051604
GO:0071456
GO:0098761
GO:0140096
GO:1900026
GO:1902175
Participates
as an output of
ERO1B oxidizes P4HB (Bos taurus)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)
as an input of
P4HB mediates disulfide bond formation in Proinsulin (Bos taurus)
Other forms of this molecule
phospho-P4HB [endoplasmic reticulum lumen]
P4HB [endoplasmic reticulum lumen]
Inferred From
HC53,56-P4HB [endoplasmic reticulum lumen]
(Homo sapiens)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 53 and 56 (in Homo sapiens)
Coordinate
53
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
OpenTargets
ENSG00000185624
Ensembl
ENSBTAP00000007943
,
ENSBTAT00000007943
,
ENSBTAG00000006045
VGNC
32538
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