Rcvrn:Ca2+ binds to and inhibits Grk1

Stable Identifier
R-BTA-3270622
Type
Reaction [binding]
Species
Bos taurus
Compartment
cytosol, photoreceptor disc membrane
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Rcvrn:Ca2+ binds to and inhibits Grk1
A substantial fraction of rhodopsin kinase (Grk1) is bound to recoverin (Rcvrn) in darkness, when internal Ca2+ levels are high. Rcvrn is an EF-hand protein that functions as a myristoyl switch. With Ca2+ bound, the myristoyl group is exposed to attach Rcvrn to the membrane. When Ca2+ levels drop with light exposure, Ca2+ dissociates from Rcvrn and Grk1 is released. Higher levels of free Grk1 accelerate the phosphorylation and shutoff of photoexcited rhodopsin (MII) (Chen et al. 1995, Dizhoor et al. 1991, Gorodovikova et al. 1994).
Literature References
PubMed ID Title Journal Year
7629115 Ca(2+)-dependent interaction of recoverin with rhodopsin kinase.

Chen, CK, Lefkowitz, RJ, Inglese, J, Hurley, JB

J Biol Chem 1995
7926045 Calcium-sensitive control of rhodopsin phosphorylation in the reconstituted system consisting of photoreceptor membranes, rhodopsin kinase and recoverin

Gorodovikova, EN, Philippov, PP, Senin, II

FEBS Lett. 1994
1672047 Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase

Brolley, D, Niemi, G, Walsh, KA, Philipov, PP, Spencer, M, Ray, S, Kumar, S, Dizhoor, AM, Hurley, JB, Stryer, L

Science 1991
Participants
Input
Output
Orthologous Events
RCVRN:Ca2+ binds to and inhibits GRK1 (Homo sapiens)
Authored
Jassal, B  (2013-04-11)
Reviewed
Makino, C  (2013-04-11)
Created
Jassal, B  (2013-04-11)
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