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DISC [plasma membrane]
Stable Identifier
R-BTA-2671814
Type
Set [DefinedSet]
Species
Bos taurus
Compartment
cytosol
,
plasma membrane
Synonyms
death-inducing signaling complex
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Caspase activation via extrinsic apoptotic signalling pathway (Bos taurus)
Caspase activation via Death Receptors in the presence of ligand (Bos taurus)
Regulation by c-FLIP (Bos taurus)
Caspase-8 and FLIP(L) processing at DISC (Bos taurus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
CASP8 activity is inhibited (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
FLIP(S) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
Participants
members
FASL:FAS Receptor Trimer:FADD [plasma membrane]
(Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Bos taurus)
Participates
as a component of
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
Inferred From
DISC [plasma membrane]
(Homo sapiens)
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