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active caspase-8 [cytosol]
Stable Identifier
R-BTA-2562550
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
CLEC7A/inflammasome pathway (Bos taurus)
ASC binds Caspase-8 complex (Bos taurus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Bos taurus)
MALT1:active caspase-8 [cytosol] (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
MALT1:active caspase-8 [cytosol] (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Caspase-8 binds MALT (Bos taurus)
MALT1:active caspase-8 [cytosol] (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Caspase-8 cleaves IL1B precursor (Bos taurus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Bos taurus)
MALT1:active caspase-8 [cytosol] (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
TRIF-mediated programmed cell death (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
N4BP1 binds IKBKG (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Apoptotic execution phase (Bos taurus)
Apoptotic cleavage of cellular proteins (Bos taurus)
Caspase-mediated cleavage of cytoskeletal proteins (Bos taurus)
Caspase mediated cleavage of vimentin at IDVD (259) (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Caspase-mediated cleavage of plectin-1 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Translocation of active caspase-8 to the mitochondrial membrane (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Caspase activation via extrinsic apoptotic signalling pathway (Bos taurus)
Caspase activation via Death Receptors in the presence of ligand (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Regulation by c-FLIP (Bos taurus)
Caspase-8 and FLIP(L) processing at DISC (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation, myristolyation of BID and translocation to mitochondria (Bos taurus)
Caspase-8 activates BID by cleavage (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
RIPK1 is cleaved by CASP8 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
RIPK3 is cleaved by CASP8 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
RIPK1 is cleaved by CASP8 (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
TRAF1 is cleaved by caspases (Bos taurus)
active caspase-8 [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Caspase-8 dimer [cytosol]
(Bos taurus)
Participates
as an input of
Caspase-8 binds MALT (Bos taurus)
Translocation of active caspase-8 to the mitochondrial membrane (Bos taurus)
as a component of
MALT1:active caspase-8 [cytosol] (Bos taurus)
as an output of
Caspase-8 processing within TLR4 complex (Bos taurus)
This entity regulates
Negatively
N4BP1 binds IKBKG
(Bos taurus)
Inferred From
active caspase-8 [cytosol]
(Homo sapiens)
active caspase-8 [cytosol]
(Homo sapiens)
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