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MDK [extracellular region]
Stable Identifier
R-BTA-2160953
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
MDK, A0A3Q1MQK5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
ALK autophosphorylation (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
MDK:ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
MDK:ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK binds JAK3 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK binds PLCG1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK binds SHC1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK dimer binds IRS1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK phosphorylates IRS1 (Bos taurus)
Active ALK:IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:pY-IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK phosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK phosphorylates PLCG1 (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK phosphorylates SHC1 (Bos taurus)
Active ALK:SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:p-3Y SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK recruits PI3K (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
MDK:ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
MDK:ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
MDK and PTN in ALK signaling (Bos taurus)
(PTN,MDK):PTPRZ oligomerizes (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
MDK [extracellular region] (Bos taurus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
MDK [extracellular region] (Bos taurus)
ALK binds ligand midkine (MDK) (Bos taurus)
MDK [extracellular region] (Bos taurus)
MDK:ALK [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
PTN and MDK bind to PTPRZ (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
MDK [extracellular region] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
MDK [extracellular region] (Bos taurus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
(PTN,MDK):ALK dimer [plasma membrane] (Bos taurus)
MDK:ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
MDK [extracellular region] (Bos taurus)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
PTPN6 dephosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
STAT3 is phosphorylated downstream of active ALK (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1MQK5
Gene Names
MDK
Reference Genes
BioGPS Gene:280852 MDK
ENSEMBL:ENSBTAG00000007740.6
Monarch:280852 MDK
NCBI Gene:280852 MDK
Reference Transcript
RefSeq:XM_005216402.3 MDK
Other Identifiers
280852
GO:0005576
GO:0007165
GO:0008083
GO:0008201
GO:0023052
GO:0048018
GO:0050896
GO:0051781
GO:0098772
Participates
as a member of
PTN,MDK [extracellular region] (Bos taurus)
as a component of
MDK:p-7Y ALK dimer [plasma membrane] (Bos taurus)
MDK:ALK [plasma membrane] (Bos taurus)
MDK:ALK dimer [plasma membrane] (Bos taurus)
MDK [extracellular region] (Bos taurus)
as an input of
ALK binds ligand midkine (MDK) (Bos taurus)
Inferred From
MDK [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_005216459.1
OpenTargets
ENSG00000110492
Ensembl
ENSBTAP00000074305
,
ENSBTAT00000078007
,
ENSBTAG00000007740
VGNC
49556
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