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YWHAZ [cytosol]
Stable Identifier
R-BTA-206099
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
YWHAZ, P63103
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G2/M Checkpoints (Bos taurus)
G2/M DNA damage checkpoint (Bos taurus)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Bos taurus)
Association of p-S216-CDC25C with 14-3-3 proteins (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
FOXO-mediated transcription (Bos taurus)
Regulation of localization of FOXO transcription factors (Bos taurus)
14-3-3 proteins bind AKT-phosphorylated FOXO1 (Bos taurus)
YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol] (Bos taurus)
YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
14-3-3 proteins bind AKT-phosphorylated FOXO3 (Bos taurus)
YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol] (Bos taurus)
YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
14-3-3 proteins bind AKT-phosphorylated FOXO4 (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
DDIT4 binds 14-3-3 dimer (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
DDIT4:14-3-3 dimer [cytosol] (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
DDIT4:14-3-3 dimer [cytosol] (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GP1b-IX-V activation signalling (Bos taurus)
GP1b-IX-V binds 14-3-3-zeta (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Rap1 signalling (Bos taurus)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Bos taurus)
14-3-3 beta, zeta [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
RAP1GAP2:14-3-3beta, zeta [cytosol] (Bos taurus)
14-3-3 beta, zeta [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Rap1 signal termination by Rap1GAPs (Bos taurus)
RAP1GAP2:14-3-3beta, zeta [cytosol] (Bos taurus)
14-3-3 beta, zeta [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BAD and translocation to mitochondria (Bos taurus)
Activation of BAD by calcineurin (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Sequestration of BAD protein by 14-3-3 (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by NOTCH (Bos taurus)
Signaling by NOTCH4 (Bos taurus)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Bos taurus)
NICD4 traffics to the nucleus (Bos taurus)
p-4S-NICD4:YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases activate PKNs (Bos taurus)
Association of p-S216-CDC25C with 14-3-3 proteins (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Bos taurus)
14-3-3 dimer [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Deactivation of the beta-catenin transactivating complex (Bos taurus)
YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Bos taurus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Bos taurus)
YWHAZ [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P63103
Gene Names
YWHAZ
Reference Genes
BioGPS Gene:287022 YWHAZ
ENSEMBL:ENSBTAG00000000236
ENSEMBL:ENSBTAG00000000236.6 YWHAZ
KEGG Gene (Bos taurus):287022 YWHAZ
Monarch:287022 YWHAZ
NCBI Gene:287022 YWHAZ
Reference Transcript
RefSeq:NM_174814.2 YWHAZ
Other Identifiers
287022
GO:0000122
GO:0001525
GO:0003016
GO:0005634
GO:0006351
GO:0006355
GO:0006605
GO:0006886
GO:0008039
GO:0012501
GO:0019904
GO:0023052
GO:0030154
GO:0030324
GO:0035148
GO:0043067
GO:0043226
GO:0048856
GO:0070371
GO:0098686
Participates
as a member of
14-3-3 beta, zeta [cytosol] (Bos taurus)
as an input of
p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)
as a component of
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Bos taurus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Bos taurus)
YWHAZ dimer [cytosol] (Bos taurus)
Other forms of this molecule
YWHAZ [nucleoplasm]
Inferred From
YWHAZ [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_777239.1
OpenTargets
ENSG00000164924
Ensembl
ENSBTAG00000000236
,
ENSBTAP00000000289
,
ENSBTAT00000000289
PRO
P63103
VGNC
53885
PDB
1A4O
,
1A38
,
2V7D
,
1A37
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.593
3
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