Reactome | phospho-CD3D [plasma membrane]

phospho-CD3D [plasma membrane]

Stable Identifier

R-BTA-202329

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

p-Y149,Y160-CD3D, Q28072

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Costimulation by the CD28 family (Bos taurus)
    - PD-1 signaling (Bos taurus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
  - TCR signaling (Bos taurus)
    - Generation of second messenger molecules (Bos taurus)
      - Phosphorylation of PLC-gamma1 (Bos taurus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
      - Phosphorylation of SLP-76 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
      - Phosphorylation of TBSMs in LAT (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
    - Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
    - Translocation of ZAP-70 to Immunological synapse (Bos taurus)
      - Activation of ZAP-70 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
      - PTPN22 dephosphorylates ZAP70 (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
      - Phosphorylation of ZAP-70 by Lck (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        phospho-CD3D [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:Q28072

Gene Names

CD3D

Reference Genes

BioGPS Gene:281053 CD3D

ENSEMBL:ENSBTAG00000006452

ENSEMBL:ENSBTAG00000006452.6 CD3D

KEGG Gene (Bos taurus):281053 CD3D

Monarch:281053 CD3D

NCBI Gene:281053 CD3D

Reference Transcript

RefSeq:NM_001034033.2 CD3D

Other Identifiers

281053

GO:0002250

GO:0002376

GO:0004888

GO:0005886

GO:0007166

GO:0009897

GO:0016020

GO:0023052

GO:0030154

GO:0042105

GO:0045059

GO:0048856

GO:0060089

Participates

as a component of

CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Bos taurus)

Other forms of this molecule

CD3D [clathrin-coated endocytic vesicle membrane]

CD3D [plasma membrane]

Inferred From

p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 149 (in Homo sapiens)

Coordinate

149

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 160 (in Homo sapiens)

Coordinate

160

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001029205.1

OpenTargets

ENSG00000167286

Ensembl

ENSBTAP00000008462, ENSBTAT00000008462, ENSBTAG00000006452

VGNC

27028

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