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phospho-MAPK7 [nucleoplasm]
Stable Identifier
R-BTA-198738
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
p-T218,Y220-MAPK7, A5PKJ4
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
Senescence-Associated Secretory Phenotype (SASP) (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
Signalling to ERK5 (Bos taurus)
ERK5 translocates to the nucleus (Bos taurus)
phospho-MAPK7 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:A5PKJ4
Gene Names
MAPK7
Reference Genes
BioGPS Gene:537703 MAPK7
ENSEMBL:ENSBTAG00000001014
KEGG Gene (Bos taurus):537703 MAPK7
Monarch:537703 MAPK7
NCBI Gene:537703 MAPK7
Reference Transcript
RefSeq:NM_001099080.2 MAPK7
RefSeq:XM_005220383.3 MAPK7
Other Identifiers
537703
GO:0000165
GO:0000166
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0007155
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0009790
GO:0010468
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0018105
GO:0019899
GO:0030154
GO:0034115
GO:0034641
GO:0035556
GO:0036003
GO:0043066
GO:0043167
GO:0043226
GO:0045765
GO:0045944
GO:0048646
GO:0048856
GO:0051019
GO:0051247
GO:0060761
GO:0070301
GO:0070885
GO:0071363
GO:0071499
GO:0071560
GO:1902176
GO:2000352
GO:2001240
Participant Of
output
ERK5 translocates to the nucleus
hasComponent
p-T1218, Y220 MAPK7 dimer [nucleoplasm]
Other forms of this molecule
MAPK7 [nucleoplasm]
MAPK7 [cytosol]
phospho-MAPK7 [cytosol]
Inferred From
p-T218,Y220-MAPK7 [nucleoplasm] (Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 220 (in Homo sapiens)
Coordinate
220
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001092550.1
,
XP_005220440.1
OpenTargets
ENSG00000166484
IntEnz
2.7.11.24
Ensembl
ENSBTAG00000001014
,
ENSBTAT00000001347
,
ENSBTAP00000001347
VGNC
31222
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