Reactome | TRAV29-1 [plasma membrane]

TRAV29-1 [plasma membrane]

Stable Identifier

R-BTA-198180

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

TCRA, A0A3Q1M3D2

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Costimulation by the CD28 family (Bos taurus)
    - PD-1 signaling (Bos taurus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Bos taurus)
    - TCR binds microbial lipid-based antigen via CD1 (Bos taurus)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
    - TCR binds self-lipid-based antigen via CD1 (Bos taurus)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Bos taurus)
      - T-cell receptor complex with CD8 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with CD8 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
  - TCR signaling (Bos taurus)
    - Downstream TCR signaling (Bos taurus)
      - Change of PKC theta conformation (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
    - Generation of second messenger molecules (Bos taurus)
      - Phosphorylation of PLC-gamma1 (Bos taurus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Phosphorylation of SLP-76 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Phosphorylation of TBSMs in LAT (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
    - Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
      - Activation of Lck (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Inactivation of LCK by PTPN22 (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Inactivation of Lck by Csk (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
    - Translocation of ZAP-70 to Immunological synapse (Bos taurus)
      - Activation of ZAP-70 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - PTPN22 dephosphorylates ZAP70 (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Phosphorylation of ZAP-70 by Lck (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        T-cell receptor [plasma membrane] (Bos taurus)
        
        TCR chain alpha [plasma membrane] (Bos taurus)
        
        TRAV29-1 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1M3D2

Gene Names

TRAV29-1

Reference Genes

ENSEMBL:ENSBTAG00000052580.1

ENSEMBL:ENSBTAG00000057034.1 TRAV29-1

Other Identifiers

GO:0042605

Participates

as a member of

TCR chain alpha [plasma membrane] (Bos taurus)

Inferred From

TCRA [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSBTAT00000081061, ENSBTAG00000057034, ENSBTAP00000064618

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